OTX1 and RGS17

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		OTX1	RGS17
Description		orthodenticle homeobox 1	regulator of G protein signaling 17
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin	Nucleus Cytoplasm Plasma Membrane Cell Junction Neuron Projection Synapse
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	Anterior/posterior Pattern Specification Metencephalon Development Midbrain Development Inner Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Diencephalon Morphogenesis	Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity
Pathways			G alpha (q) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events
Drugs
Diseases
GWAS		Neurociticism ( 29500382) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258)	Alcohol dependence ( 26365420) Bacterial meningitis ( 31092817) Body mass index ( 28892062) Cuneus cortex volume ( 31530798) Diastolic blood pressure ( 30224653) General risk tolerance (MTAG) ( 30643258) High density lipoprotein cholesterol levels ( 29083408) Lipoprotein (a) levels ( 26377243) Morning person ( 30696823) Pneumococcal meningitis ( 31092817) Prostate cancer ( 23535732)
Interacting Genes		47 interacting genes: ADAMTSL4 CHIC2 CHRD COMP DPY30 FBLN5 GEMIN8P4 GRN KCNK16 KRT81 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-4 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2A LCE2D LCE4A MDFI MGAT5B MTNR1B RBPMS RGS17 RGS20 SMARCC1 SPRY1 SPRY2 TLE4 TNS2 VWC2L	18 interacting genes: ADRB2 AQP1 DHX37 GNAI1 GNAI3 HOXA1 LCE2A LCE3C LCE4A NUFIP2 OSTM1 OTX1 PTGER3 RABEP1 RBBP8 RPL10A SMCP TBC1D16
Entrez ID		5013	26575
HPRD ID		08964	06223
Ensembl ID		ENSG00000115507	ENSG00000091844
Uniprot IDs		P32242	Q9UGC6
PDB IDs			1ZV4 6AM3
Enriched GO Terms of Interacting Partners?
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