GRN and TAT

Number of citations of the paper that reports this interaction (PubMedID 12588988)
31

Data Source:
BioGRID (pull down, affinity chromatography technology)

		GRN	TAT
Description		granulin precursor	tyrosine aminotransferase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Lysosome Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Azurophil Granule Lumen Extracellular Exosome	Cellular_component Mitochondrion Cytosol
	Molecular Function	RNA Binding Cytokine Activity Protein Binding Growth Factor Activity Chaperone Binding	L-tyrosine:2-oxoglutarate Aminotransferase Activity Protein Binding Amino Acid Binding Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Astrocyte Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cell Migration Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Axon Regeneration Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Protein Stabilization Regulation Of Nervous System Development Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Neutrophil Activation Positive Regulation Of Protein Folding Negative Regulation Of Microglial Cell Activation Positive Regulation Of Aspartic-type Peptidase Activity Positive Regulation Of Lysosome Organization	2-oxoglutarate Metabolic Process Glutamate Metabolic Process L-phenylalanine Catabolic Process Tyrosine Catabolic Process Response To Oxidative Stress Biosynthetic Process Response To Mercury Ion Response To Glucocorticoid
Pathways		Neutrophil degranulation	Tyrosine catabolism
Drugs			Pyridoxal Phosphate L-Phenylalanine L-Tyrosine Glutamic Acid
Diseases		Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)	Tyrosinemia; Tyrosinemia, type I; Tyrosinemia, type II; Tyrosinemia, type III; Hawkinsinuria
GWAS		Blood protein levels ( 30072576 29875488) Intracranial volume ( 22504418) Progranulin levels ( 29186428) Subcortical brain region volumes ( 25607358)	Chronotype ( 30696823) Metabolite levels ( 22286219 22916037) Morning person ( 30696823) Urate levels ( 31578528)
Interacting Genes		38 interacting genes: ARFGAP1 ATN1 ATXN7 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CRKL CRY1 DLK1 DLX2 ELANE FAM131C FANCL FRAT1 GFI1B GLRX3 HK3 HOXA1 HSPG2 KRT18 KRTAP10-7 KRTAP26-1 NLK OTX1 PIK3R2 POT1 PRKAB2 RAC1 SGTA SLPI SMAD9 SPRY2 TAT TGM2 TOP3B YY1	3 interacting genes: GLUL GRN UBE3A
Entrez ID		2896	6898
HPRD ID		00733	11776
Ensembl ID		ENSG00000030582	ENSG00000198650
Uniprot IDs		P28799	A0A140VKB7 P17735
PDB IDs		1G26 2JYE 2JYT 2JYU 2JYV	3DYD
Enriched GO Terms of Interacting Partners?
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