OPRM1 and PPL

Number of citations of the paper that reports this interaction (PubMedID 12810704)
11

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		OPRM1	PPL
Description		opioid receptor mu 1	periplakin
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Axon Dendrite Dendrite Membrane Dendrite Cytoplasm Sarcolemma Neuron Projection Perikaryon Membrane Raft Spine Apparatus Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Cornified Envelope Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Intermediate Filament Membrane Desmosome Extracellular Exosome
	Molecular Function	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Beta-endorphin Receptor Activity Voltage-gated Calcium Channel Activity Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Filamin Binding G-protein Beta-subunit Binding Morphine Receptor Activity Peptide Binding Neuropeptide Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding
	Biological Process	Acute Inflammatory Response To Antigenic Stimulus G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Sensory Perception Locomotory Behavior Negative Regulation Of Cell Proliferation Response To Radiation Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Response To Food Positive Regulation Of Appetite Response To Lipopolysaccharide Opioid Receptor Signaling Pathway Wound Healing Response To Cocaine Eating Behavior Estrous Cycle Behavioral Response To Ethanol Positive Regulation Of Neurogenesis Regulation Of Sensory Perception Of Pain Excitatory Postsynaptic Potential Negative Regulation Of Wnt Protein Secretion Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Response To Growth Factor Cellular Response To Morphine Regulation Of Cellular Response To Stress Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of NMDA Receptor Activity	Response To Mechanical Stimulus Wound Healing Intermediate Filament Cytoskeleton Organization Cornification
Pathways		Opioid Signalling G-protein activation Peptide ligand-binding receptors G alpha (i) signalling events Interleukin-4 and Interleukin-13 signaling MECP2 regulates neuronal receptors and channels	Formation of the cornified envelope Butyrophilin (BTN) family interactions
Drugs		Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Pethidine Oxycodone Levallorphan Dextromethorphan Butorphanol Dextropropoxyphene Pentazocine Naltrexone Sufentanil Alfentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Ondansetron Anileridine Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Dezocine Ketamine Levomethadyl Acetate Methadyl Acetate 3-Methylthiofentanyl Dimethylthiambutene Heroin Ethylmorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl V1003 Epicept NP-1 LI-301 Tapentadol Nalmefene Alvimopan Ketobemidone Methylnaltrexone Naloxegol Trimebutine Eluxadoline Propoxyphene napsylate Naldemedine
Diseases
GWAS		Diastolic blood pressure ( 30224653) Hypertension ( 21347282) Lipoprotein (a) levels ( 26377243) Menstruation quality of life impact (fever) ( 29855537) Methadone dose in opioid dependence ( 28115739) Type 2 diabetes (age of onset) ( 28060188)	Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878)
Interacting Genes		22 interacting genes: CALM1 COPS5 DNAJB4 DOK4 DOK5 FLNA GNA15 GNAI1 GNAI2 GNAO1 GPRASP1 GRK3 KCNF1 OPRD1 PLD2 PPL SIAH1 SIAH2 UBC VAPA WLS ZYX	24 interacting genes: AHCYL1 AKT1 ALAS1 CASP6 CEP57L1 COL17A1 EVPL ITSN1 KAZN KRT8 LARP1 OPRM1 PPHLN1 PTEN RAB3IP RALBP1 SKIL TRAF2 TRIM27 TSC22D4 UBC USP7 VIM ZSCAN1
Entrez ID		4988	5493
HPRD ID		02484	04187
Ensembl ID		ENSG00000112038	ENSG00000118898
Uniprot IDs		B8K2Q5 G8XRH4 G8XRH5 L0E130 P35372	O60437
PDB IDs			4Q28
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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