OPRM1 and WLS

Number of citations of the paper that reports this interaction (PubMedID 23840749)
10

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)

		OPRM1	WLS
Description		opioid receptor mu 1	Wnt ligand secretion mediator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Axon Dendrite Dendrite Membrane Dendrite Cytoplasm Sarcolemma Neuron Projection Perikaryon Membrane Raft Spine Apparatus Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Golgi Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Endocytic Vesicle Membrane Integral Component Of Organelle Membrane Cytoplasmic Vesicle Early Endosome Membrane Dendrite Membrane Dendrite Cytoplasm Extracellular Exosome
	Molecular Function	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Beta-endorphin Receptor Activity Voltage-gated Calcium Channel Activity Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Filamin Binding G-protein Beta-subunit Binding Morphine Receptor Activity Peptide Binding Neuropeptide Binding	Protein Binding Wnt-protein Binding Mu-type Opioid Receptor Binding
	Biological Process	Acute Inflammatory Response To Antigenic Stimulus G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Sensory Perception Locomotory Behavior Negative Regulation Of Cell Proliferation Response To Radiation Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Response To Food Positive Regulation Of Appetite Response To Lipopolysaccharide Opioid Receptor Signaling Pathway Wound Healing Response To Cocaine Eating Behavior Estrous Cycle Behavioral Response To Ethanol Positive Regulation Of Neurogenesis Regulation Of Sensory Perception Of Pain Excitatory Postsynaptic Potential Negative Regulation Of Wnt Protein Secretion Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Response To Growth Factor Cellular Response To Morphine Regulation Of Cellular Response To Stress Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of NMDA Receptor Activity	Mesoderm Formation Intracellular Protein Transport Anterior/posterior Axis Specification Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Midbrain Development Hindbrain Development Exocrine Pancreas Development Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Wnt Protein Secretion Positive Regulation Of Wnt Protein Secretion Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Opioid Signalling G-protein activation Peptide ligand-binding receptors G alpha (i) signalling events Interleukin-4 and Interleukin-13 signaling MECP2 regulates neuronal receptors and channels	WNT ligand biogenesis and trafficking
Drugs		Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Pethidine Oxycodone Levallorphan Dextromethorphan Butorphanol Dextropropoxyphene Pentazocine Naltrexone Sufentanil Alfentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Ondansetron Anileridine Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Dezocine Ketamine Levomethadyl Acetate Methadyl Acetate 3-Methylthiofentanyl Dimethylthiambutene Heroin Ethylmorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl V1003 Epicept NP-1 LI-301 Tapentadol Nalmefene Alvimopan Ketobemidone Methylnaltrexone Naloxegol Trimebutine Eluxadoline Propoxyphene napsylate Naldemedine
Diseases
GWAS		Diastolic blood pressure ( 30224653) Hypertension ( 21347282) Lipoprotein (a) levels ( 26377243) Menstruation quality of life impact (fever) ( 29855537) Methadone dose in opioid dependence ( 28115739) Type 2 diabetes (age of onset) ( 28060188)	Bone mineral density (spine) ( 26911590) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Perceived intensity of sucrose ( 31005972) Postoperative complication after cardiac surgery ( 30678657) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		22 interacting genes: CALM1 COPS5 DNAJB4 DOK4 DOK5 FLNA GNA15 GNAI1 GNAI2 GNAO1 GPRASP1 GRK3 KCNF1 OPRD1 PLD2 PPL SIAH1 SIAH2 UBC VAPA WLS ZYX	1 interacting genes: OPRM1
Entrez ID		4988	79971
HPRD ID		02484	10980
Ensembl ID		ENSG00000112038	ENSG00000116729
Uniprot IDs		B8K2Q5 G8XRH4 G8XRH5 L0E130 P35372	Q5T9L3
PDB IDs
Enriched GO Terms of Interacting Partners?
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