MAP4K4 and NME7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MAP4K4	NME7
Description		mitogen-activated protein kinase kinase kinase kinase 4	NME/NM23 family member 7
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Focal Adhesion	Centrosome Cytosol
	Molecular Function	Creatine Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding	Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Microvillus Assembly Positive Regulation Of Cell Migration Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of ARF Protein Signal Transduction Activation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of JNK Cascade Neuron Projection Morphogenesis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Disassembly	Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process
Pathways		Oxidative Stress Induced Senescence	Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes
Drugs
Diseases
GWAS		Alzheimer's disease ( 30636644) Asthma ( 31619474) Asthma (time to onset) ( 27130862) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Coronary artery disease ( 29212778) D-dimer levels ( 21502573) Pulse pressure ( 27841878 30578418) QT interval ( 30679814) Systolic blood pressure ( 27841878 30578418) Venous thromboembolism ( 21980494 22672568)
Interacting Genes		18 interacting genes: BRCA1 CASP8 DOK1 GBP3 H2BC21 ITGB1 KIF26B KIF5A MAP3K7 NCK1 NME7 PPP1CA PPP1CC PRKCE RAP2A RASA1 SLC9A1 TBPL2	28 interacting genes: C1orf189 CCHCR1 CDC42EP2 CEP72 DDX1 FKBP6 FOSL1 GOLGA2 IKZF1 KRT18 LNX1 MAP4K4 MYOT NAB2 NEFL NT5C2 OFD1 REL SHTN1 SYCE1 TCF4 TCHP TNIP1 TRIM27 TUFT1 YWHAQ ZBTB48 ZNF263
Entrez ID		9448	29922
HPRD ID		05235	11394
Ensembl ID		ENSG00000071054	ENSG00000143156
Uniprot IDs		B7Z3V5 O95819 V9HWH3	A0A024R8Z7 Q9Y5B8
PDB IDs		4OBO 4OBP 4OBQ 4RVT 4U3Y 4U3Z 4U40 4U41 4U42 4U43 4U44 4U45 4ZK5 4ZP5 5DI1 5J95 5W5Q
Enriched GO Terms of Interacting Partners?
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