IHO1 and AQP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		IHO1	AQP1
Description		interactor of HORMAD1 1	aquaporin 1 (Colton blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome	Cell Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Basal Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Symbiont-containing Vacuole Symbiont-containing Vacuole Membrane Brush Border Membrane Nuclear Membrane Sarcolemma Apical Part Of Cell Extracellular Exosome
	Molecular Function	Protein Binding	Intracellular CGMP-activated Cation Channel Activity Potassium Channel Activity Water Transmembrane Transporter Activity Protein Binding Ammonium Transmembrane Transporter Activity Potassium Ion Transmembrane Transporter Activity Glycerol Transmembrane Transporter Activity Water Channel Activity Transmembrane Transporter Activity Nitric Oxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transporter Activity Identical Protein Binding
	Biological Process	DNA Recombination Synapsis Spermatogenesis Meiotic DNA Double-strand Break Formation Oogenesis Regulation Of Homologous Chromosome Segregation	Renal Water Homeostasis Renal Water Transport Potassium Ion Transport Water Transport Cell Volume Homeostasis Hyperosmotic Response Cellular Water Homeostasis Carbon Dioxide Transport Ammonium Transport Bicarbonate Transport Glycerol Transport Cellular Homeostasis CGMP-mediated Signaling Lateral Ventricle Development Pancreatic Juice Secretion Nitric Oxide Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Cellular Response To UV Transepithelial Water Transport Carbon Dioxide Transmembrane Transport Odontogenesis Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Saliva Secretion Positive Regulation Of Fibroblast Proliferation Multicellular Organismal Water Homeostasis Cellular Response To Hydrogen Peroxide Cellular Response To Inorganic Substance Cellular Response To Mechanical Stimulus Cellular Response To Copper Ion Cellular Response To Mercury Ion Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Hypoxia Cellular Response To Salt Stress Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Potassium Ion Transmembrane Transport Ammonium Transmembrane Transport Maintenance Of Symbiont-containing Vacuole By Host
Pathways			Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs			Acetazolamide
Diseases
GWAS			Fractures ( 30598549) Heel bone mineral density ( 30598549 28869591) Huntington's disease progression ( 28642124) Kidney stones ( 31729369) Nephrolithiasis ( 22396660) Systolic blood pressure ( 30224653) Total body bone mineral density ( 29304378)
Interacting Genes		50 interacting genes: ABI2 AQP1 ARHGEF9 ATP6V0D1 BCL6 C1orf109 CARD9 CDC23 COX5B DGCR6 DVL2 DYNLL1 DYNLL2 EAF2 EFHC1 FAM124A FANCG FANCL FHL3 FKBP6 GLRX3 GOLGA2 GRAP2 GYS1 HEXIM2 HINFP IQUB KANK2 KLC3 LMO2 LONRF1 MRFAP1L1 MVP MYO15B NEK6 NGB POLR1C PRKAB2 RAD51D RUNX1T1 SDCBP SMARCB1 STK25 TNS2 TRIM42 TTC19 USP2 USP20 ZGPAT ZNF688	44 interacting genes: ADAMTSL4 CCDC136 CCDC57 CCDC85B CEP44 CREB3 CRTAC1 CSRNP1 EFEMP2 EPHB2 FOS FSD2 IHO1 IKZF2 IKZF3 KCTD17 KCTD9 KIAA1958 KRT31 KRT33B KRT40 KRTAP10-3 KRTAP10-7 KRTAP4-12 KRTAP4-2 KRTAP9-2 LMNA MDFI MID2 MTUS2 NBPF22P NOTCH2NLA PICK1 RGS17 RGS20 RIMBP3 SIAH1 SPRY2 TCF4 TNK2 TRAF1 TRAF2 TRIM23 TRIP6
Entrez ID		339834	358
HPRD ID		14172	00140
Ensembl ID		ENSG00000173421	ENSG00000240583
Uniprot IDs		B4DZP6 Q8IYA8	A0A024RA31 P29972
PDB IDs			1FQY 1H6I 1IH5 4CSK 6POJ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?