IHO1 and POLR1C

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		IHO1	POLR1C
Description		interactor of HORMAD1 1	RNA polymerase I and III subunit C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome	Nucleoplasm RNA Polymerase III Complex RNA Polymerase I Complex Cytosol
	Molecular Function	Protein Binding	RNA Polymerase I Activity RNA Polymerase III Activity DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein Dimerization Activity
	Biological Process	DNA Recombination Synapsis Spermatogenesis Meiotic DNA Double-strand Break Formation Oogenesis Regulation Of Homologous Chromosome Segregation	Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase III Positive Regulation Of Type I Interferon Production Positive Regulation Of Gene Expression, Epigenetic
Pathways			Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases			Treacher Collins syndrome
GWAS			GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		50 interacting genes: ABI2 AQP1 ARHGEF9 ATP6V0D1 BCL6 C1orf109 CARD9 CDC23 COX5B DGCR6 DVL2 DYNLL1 DYNLL2 EAF2 EFHC1 FAM124A FANCG FANCL FHL3 FKBP6 GLRX3 GOLGA2 GRAP2 GYS1 HEXIM2 HINFP IQUB KANK2 KLC3 LMO2 LONRF1 MRFAP1L1 MVP MYO15B NEK6 NGB POLR1C PRKAB2 RAD51D RUNX1T1 SDCBP SMARCB1 STK25 TNS2 TRIM42 TTC19 USP2 USP20 ZGPAT ZNF688	35 interacting genes: ATRIP BIRC7 CBY2 CCDC33 CD3EAP CLU CORO1A CORO1B IHO1 IKZF3 KCTD1 KRT19 LNX2 LZTS2 MBIP MKRN3 MYD88 MYO5B NFKBIB NME1 POLR1D POLR1E PPP2R3C RIMBP3 SAXO1 SMN2 TASOR2 TCF4 TFIP11 TNFAIP1 TRIM27 TRIOBP TSC22D4 VIM WRN
Entrez ID		339834	9533
HPRD ID		14172	09661
Ensembl ID		ENSG00000173421	ENSG00000171453
Uniprot IDs		B4DZP6 Q8IYA8	O15160
PDB IDs
Enriched GO Terms of Interacting Partners?
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