AQP1 and MTUS2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		AQP1	MTUS2
Description		aquaporin 1 (Colton blood group)	microtubule associated scaffold protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Basal Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Symbiont-containing Vacuole Symbiont-containing Vacuole Membrane Brush Border Membrane Nuclear Membrane Sarcolemma Apical Part Of Cell Extracellular Exosome	Nucleus Cytoplasm Centrosome Cytoplasmic Microtubule
	Molecular Function	Intracellular CGMP-activated Cation Channel Activity Potassium Channel Activity Water Transmembrane Transporter Activity Protein Binding Ammonium Transmembrane Transporter Activity Potassium Ion Transmembrane Transporter Activity Glycerol Transmembrane Transporter Activity Water Channel Activity Transmembrane Transporter Activity Nitric Oxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transporter Activity Identical Protein Binding	Protein Binding Microtubule Binding Protein Homodimerization Activity
	Biological Process	Renal Water Homeostasis Renal Water Transport Potassium Ion Transport Water Transport Cell Volume Homeostasis Hyperosmotic Response Cellular Water Homeostasis Carbon Dioxide Transport Ammonium Transport Bicarbonate Transport Glycerol Transport Cellular Homeostasis CGMP-mediated Signaling Lateral Ventricle Development Pancreatic Juice Secretion Nitric Oxide Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Cellular Response To UV Transepithelial Water Transport Carbon Dioxide Transmembrane Transport Odontogenesis Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Saliva Secretion Positive Regulation Of Fibroblast Proliferation Multicellular Organismal Water Homeostasis Cellular Response To Hydrogen Peroxide Cellular Response To Inorganic Substance Cellular Response To Mechanical Stimulus Cellular Response To Copper Ion Cellular Response To Mercury Ion Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Hypoxia Cellular Response To Salt Stress Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Potassium Ion Transmembrane Transport Ammonium Transmembrane Transport Maintenance Of Symbiont-containing Vacuole By Host
Pathways		Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs		Acetazolamide
Diseases
GWAS		Fractures ( 30598549) Heel bone mineral density ( 30598549 28869591) Huntington's disease progression ( 28642124) Kidney stones ( 31729369) Nephrolithiasis ( 22396660) Systolic blood pressure ( 30224653) Total body bone mineral density ( 29304378)	Insomnia (caffeine-induced) ( 22754043) Obesity-related traits ( 23251661) Triptolide cytotoxicity ( 26121980)
Interacting Genes		44 interacting genes: ADAMTSL4 CCDC136 CCDC57 CCDC85B CEP44 CREB3 CRTAC1 CSRNP1 EFEMP2 EPHB2 FOS FSD2 IHO1 IKZF2 IKZF3 KCTD17 KCTD9 KIAA1958 KRT31 KRT33B KRT40 KRTAP10-3 KRTAP10-7 KRTAP4-12 KRTAP4-2 KRTAP9-2 LMNA MDFI MID2 MTUS2 NBPF22P NOTCH2NLA PICK1 RGS17 RGS20 RIMBP3 SIAH1 SPRY2 TCF4 TNK2 TRAF1 TRAF2 TRIM23 TRIP6	181 interacting genes: - AEN AFF4 AKT1 AQP1 ARNT2 AXIN1 BCL6 BMP7 BYSL C1orf109 C1orf216 C21orf58 C2CD6 C8orf34 CATIP CATSPER1 CBX8 CCDC116 CCDC146 CCDC17 CCDC198 CCDC60 CCHCR1 CDC20B CDC73 CDK18 CDK5R1 CDKL3 CEP57L1 CEP95 CERK COG2 CREB5 CRY2 CTSZ CWF19L2 CXCL11 CXCL16 DCDC2B DCTN4 DLGAP5 DMRT3 DOCK2 DTNB FAM110A FAM13C FAM161A FAM71E2 FAM74A4 FAM90A1 FBXL18 FBXO34 FCHSD2 FHL3 FNDC11 GAL3ST2 GOLGA2P11 GRAP2 GTF2I GTPBP10 HAUS1 HCK HDAC4 HSF2 IQCE ITGB5 ITSN1 KAT5 KIF1A KRT6A LENG1 LIMS2 LINC00636 LMO2 LNX1 LRR1 LYSMD1 MAGEA8 MARK4 MFAP1 MRPL11 MTMR6 NDEL1 NDOR1 NEFL NELFE NTAQ1 NUBPL NUDT10 ODF1 PDE4DIP PIN1 PKP2 PLK4 PLSCR4 POLDIP2 POLDIP3 PPHLN1 PPP1R18 PRKAA1 PRPF31 PSMA1 PTPMT1 RAB3IL1 RGS2 RHPN1 RIBC2 RNF6 ROBO3 RPA1 RPL9 RTP5 SCEL SCNM1 SDCBP SELENOM SETD5 SH2D4A SH3RF2 SHFL SLC23A1 SLC25A6 SLIRP SMARCE1 SNAI1 SNHG11 SNRPA SNRPB2 SNW1 SPATA8 SPG7 STK16 SYT6 TAF13 TEAD4 THAP7 TLE5 TP53RK TRIM42 TSGA10IP TSHZ3 TULP2 TXN2 USP2 WAC ZBTB38 ZC2HC1C ZFC3H1 ZFP2 ZFP64 ZFYVE21 ZMAT2 ZNF136 ZNF20 ZNF224 ZNF232 ZNF250 ZNF3 ZNF329 ZNF337 ZNF410 ZNF415 ZNF417 ZNF426 ZNF439 ZNF440 ZNF490 ZNF557 ZNF572 ZNF581 ZNF587 ZNF599 ZNF607 ZNF624 ZNF655 ZNF670 ZNF785 ZNF844 ZSCAN12 ZSCAN26
Entrez ID		358	23281
HPRD ID		00140	11108
Ensembl ID		ENSG00000240583	ENSG00000132938
Uniprot IDs		A0A024RA31 P29972	J3KQA9 Q5JR59
PDB IDs		1FQY 1H6I 1IH5 4CSK 6POJ
Enriched GO Terms of Interacting Partners?
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