TLX3 and TLE2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		TLX3	TLE2
Description		T cell leukemia homeobox 3	TLE family member 2, transcriptional corepressor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm	Extracellular Space Nucleus Nucleoplasm Transcription Factor Complex Focal Adhesion Nuclear Body
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding
	Biological Process	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Neurological System Process Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Respiratory Gaseous Exchange Negative Regulation Of Neuron Differentiation Neuron Fate Specification	Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly
Pathways			Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS
Interacting Genes		16 interacting genes: DENND4A GTF2A1L H2BC11 HNRNPUL1 HOPX ING4 IRF9 LMO2 MEIS1 PPP1CC PQBP1 SNTA1 SP1 TLE1 TLE2 ZNF41	16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX
Entrez ID		30012	7089
HPRD ID		06868	03025
Ensembl ID		ENSG00000164438	ENSG00000065717
Uniprot IDs		O43711	K7EMK7 Q04725
PDB IDs
Enriched GO Terms of Interacting Partners?
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