TLX3 and ING4

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		TLX3	ING4
Description		T cell leukemia homeobox 3	inhibitor of growth family member 4
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytosol Intermediate Filament Cytoskeleton
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding	Transcription Coactivator Activity Protein Binding Methylated Histone Binding Metal Ion Binding
	Biological Process	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Neurological System Process Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Respiratory Gaseous Exchange Negative Regulation Of Neuron Differentiation Neuron Fate Specification	DNA Replication Protein Acetylation Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Cell Cycle Arrest Negative Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Growth Positive Regulation Of Nucleic Acid-templated Transcription
Pathways			HATs acetylate histones
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS
Interacting Genes		16 interacting genes: DENND4A GTF2A1L H2BC11 HNRNPUL1 HOPX ING4 IRF9 LMO2 MEIS1 PPP1CC PQBP1 SNTA1 SP1 TLE1 TLE2 ZNF41	16 interacting genes: CDC34 EGLN1 EP300 H3-4 H3C1 HNRNPD HOXB9 KAT7 MAPK8IP2 MSX1 MYC NAV2 RELA SUV39H1 TLX3 TP53
Entrez ID		30012	51147
HPRD ID		06868	09774
Ensembl ID		ENSG00000164438	ENSG00000111653
Uniprot IDs		O43711	Q9UNL4
PDB IDs			2K1J 2M1R 2PNX 2VNF 4AFL
Enriched GO Terms of Interacting Partners?
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