TLE2 and RUNX1

Number of citations of the paper that reports this interaction (PubMedID 10825294)
73

Data Source:
HPRD (in vivo)

		TLE2	RUNX1
Description		TLE family member 2, transcriptional corepressor	RUNX family transcription factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Transcription Factor Complex Focal Adhesion Nuclear Body	Nuclear Chromatin Nucleus Nucleoplasm Core-binding Factor Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding ATP Binding Transcription Regulatory Region DNA Binding
	Biological Process	Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Ossification Regulation Of Cytokine-mediated Signaling Pathway Chondrocyte Differentiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Hemopoiesis Regulation Of Wnt Signaling Pathway Neuron Differentiation Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Interleukin-2 Production Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Regulatory T Cell Differentiation Regulation Of Cell Differentiation Regulation Of Keratinocyte Differentiation Regulation Of Myeloid Cell Differentiation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Peripheral Nervous System Neuron Development Regulation Of B Cell Receptor Signaling Pathway Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Bicellular Tight Junction Assembly
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes	Pre-NOTCH Transcription and Translation Organic cation transport RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates estrogen receptor mediated transcription Regulation of RUNX1 Expression and Activity Regulation of RUNX1 Expression and Activity RUNX1 regulates expression of components of tight junctions RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX1 regulates transcription of genes involved in interleukin signaling RUNX1 regulates transcription of genes involved in WNT signaling RUNX2 regulates genes involved in differentiation of myeloid cells RUNX3 regulates p14-ARF Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis
Drugs
Diseases			Chronic myeloid leukemia (CML) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM) Acute myeloid leukemia (AML) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS			3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 30929738 31619474) Asthma (adult onset) ( 31036433 30929738) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Breast cancer ( 31757997) Celiac disease and Rheumatoid arthritis ( 26546613) Core binding factor acute myeloid leukemia ( 27903959) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Esophageal cancer ( 21642993) Esophageal squamous cell carcinoma ( 25129146) Femoral neck length ( 30888730) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) Immune response to smallpox vaccine (IL-6) ( 22542470) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Male-pattern baldness ( 29146897 27182965 28196072) Medication use (adrenergics, inhalants) ( 31015401) Neutrophil percentage of granulocytes ( 27863252) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Platelet count ( 27863252) Plateletcrit ( 27863252) Preeclampsia ( 23551011) Psoriasis ( 25903422) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX	54 interacting genes: AR CBFA2T2 CBFA2T3 CBFB CCND1 CCND2 CCND3 CDK1 CDK6 CEBPA CEBPB COL6A1 COPRS CTBP2 DNMT1 DTX2 DZIP3 ELF1 ELF2 ELF4 EP300 FOS FOXP3 HIPK1 HIPK2 IKZF1 IKZF3 JUN KAT6A KAT6B MYOD1 NCOR1 NCOR2 NEDD4 PAX5 PRMT1 RBM14 RNF38 RNF44 SPEN SPI1 SUV39H1 TAZ TLE1 TLE2 TLE5 TRIM5 UBE2L6 UHRF2 UXT VDR WWP1 WWTR1 YAP1
Entrez ID		7089	861
HPRD ID		03025	01043
Ensembl ID		ENSG00000065717	ENSG00000159216
Uniprot IDs		K7EMK7 Q04725	Q01196
PDB IDs			1CMO 1CO1 1E50 1H9D 1LJM
Enriched GO Terms of Interacting Partners?
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