TLX3 and H2BC11

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		TLX3	H2BC11
Description		T cell leukemia homeobox 3	H2B clustered histone 11
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm	Nucleosome Extracellular Space Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding	Lipopolysaccharide Binding DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Neurological System Process Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Respiratory Gaseous Exchange Negative Regulation Of Neuron Differentiation Neuron Fate Specification	Innate Immune Response In Mucosa Nucleosome Assembly Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Antibacterial Humoral Response Killing Of Cells Of Other Organism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Amyloid fiber formation
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS
Interacting Genes		16 interacting genes: DENND4A GTF2A1L H2BC11 HNRNPUL1 HOPX ING4 IRF9 LMO2 MEIS1 PPP1CC PQBP1 SNTA1 SP1 TLE1 TLE2 ZNF41	3 interacting genes: JMJD6 LOX TLX3
Entrez ID		30012	8970
HPRD ID		06868	13657
Ensembl ID		ENSG00000164438	ENSG00000124635
Uniprot IDs		O43711	A0A024RCJ2 P06899
PDB IDs			2RVQ 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3W96 3W97 3W98 3W99 3WA9 3WAA 3WTP 4CAY 4YM5 4YM6 4Z5T 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5AY8 5B0Y 5B0Z 5B24 5B2I 5B2J 5B31 5B32 5B33 5B40 5CPI 5CPJ 5CPK 5FUG 5GSE 5GTC 5GXQ 5JRG 5VEY 5X7X 5XF3 5XF4 5XF5 5Y0C 5Y0D 5Z23 5Z30 5ZBX 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6BUZ 6E0C 6E0P 6HKT 6HTS 6INQ 6IQ4 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6JR0 6JR1 6O1D 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94
Enriched GO Terms of Interacting Partners?
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