TLX3 and DENND4A

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		TLX3	DENND4A
Description		T cell leukemia homeobox 3	DENN domain containing 4A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm	Nucleus Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding	DNA Binding Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Neurological System Process Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Respiratory Gaseous Exchange Negative Regulation Of Neuron Differentiation Neuron Fate Specification	Regulation Of Transcription, DNA-templated
Pathways			RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS			Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Hemoglobin concentration ( 27863252) Intelligence (MTAG) ( 29326435) Logical memory (delayed recall) in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 29403010 20139978 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Red blood cell count ( 27863252) Red blood cell traits ( 23222517)
Interacting Genes		16 interacting genes: DENND4A GTF2A1L H2BC11 HNRNPUL1 HOPX ING4 IRF9 LMO2 MEIS1 PPP1CC PQBP1 SNTA1 SP1 TLE1 TLE2 ZNF41	6 interacting genes: CEBPE CLK1 PCBD1 SERTAD1 TLX3 YWHAG
Entrez ID		30012	10260
HPRD ID		06868	02662
Ensembl ID		ENSG00000164438	ENSG00000174485
Uniprot IDs		O43711	Q05C90 Q7Z401
PDB IDs
Enriched GO Terms of Interacting Partners?
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