TLE2 and EMX2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		TLE2	EMX2
Description		TLE family member 2, transcriptional corepressor	empty spiracles homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Transcription Factor Complex Focal Adhesion Nuclear Body	Nuclear Chromatin Nucleus
	Molecular Function	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Anterior/posterior Pattern Specification Dentate Gyrus Development Cerebral Cortex Regionalization Cell Proliferation In Forebrain Forebrain Cell Migration Neuron Differentiation Response To Drug Ureter Morphogenesis
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases
GWAS			Airflow obstruction ( 22837378) Celiac disease ( 23936387) Chronotype ( 30696823) Double-edged eyelids ( 29895819) Early cardiac repolarization ( 22683750) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Low tan response ( 29739929) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Pulmonary function in asthmatics ( 23541324) Response to quetiapine in schizophrenia ( 29503163) Serum uric acid levels ( 30993211 29403010) Skin pigmentation ( 30664655) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Urate levels ( 31578528)
Interacting Genes		16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX	4 interacting genes: EIF4E GTF2A1L MEIS1 TLE2
Entrez ID		7089	2018
HPRD ID		03025	02495
Ensembl ID		ENSG00000065717	ENSG00000170370
Uniprot IDs		K7EMK7 Q04725	Q04743
PDB IDs
Enriched GO Terms of Interacting Partners?
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