LSM3 and KEAP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LSM3	KEAP1
Description		LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated	kelch like ECH associated protein 1
Image
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Actin Filament Inclusion Body Midbody Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite
	Molecular Function	RNA Binding Protein Binding U6 SnRNA 3'-end Binding	Protein Binding Transcription Factor Binding Identical Protein Binding Disordered Domain Specific Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Cytoplasmic MRNA Processing Body Assembly Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Viral Process Protein Ubiquitination Protein Deubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway	Ub-specific processing proteases Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Dimethyl fumarate Artenimol
Diseases
GWAS		Chronotype ( 30696823) Height ( 31562340) Offspring birth weight ( 31043758)	Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		40 interacting genes: CCND3 CDKN2D CEP95 CLNS1A CNOT7 DLX4 EEF1A1 EIF4EBP2 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 KEAP1 KLF3 LSM1 LSM10 LSM2 LSM5 LSM6 LSM7 LSM8 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD1 SNRPD3 SNRPE SNRPG TCL1A TFIP11 THOC5 UTP14A WDR77 WDR83 XPC XRN2 YBX1	49 interacting genes: AK4 AMER1 ATG5 BAD BPTF CAT CCNB1IP1 CDH1 CDK6 CLU CPEB2 CTTN CUL3 EGFR ETF1 FAM117B GLRX5 GYPA HSP90AA1 HSP90AB1 IPO11 IRF1 KLHL3 KPNA6 LSM3 MAD2L1 MAPKBP1 MYO7A NFE2L2 NUDT4 OXR1 PDCD6IP PIDD1 PPP1R13L PRKAG1 PTMA RAF1 RECK RELA SNRPN STK3 STK4 TENT5A TERF1 TRIM15 UBC USP15 WDR83 ZSCAN32
Entrez ID		27258	9817
HPRD ID		06283	12079
Ensembl ID		ENSG00000170860	ENSG00000079999
Uniprot IDs		P62310	A0A024R7C0 Q14145
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B 4XMB 5DAD 5DAF 5F72 5GIT 5NLB 5WFL 5WFV 5WG1 5WHL 5WHO 5WIY 5X54 6FFM 6FMP 6FMQ 6HWS 6ROG
Enriched GO Terms of Interacting Partners?
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