KEAP1 and GYPA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		KEAP1	GYPA
Description		kelch like ECH associated protein 1	glycophorin A (MNS blood group)
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Actin Filament Inclusion Body Midbody Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite	Nucleoplasm Cytosol Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Transcription Factor Binding Identical Protein Binding Disordered Domain Specific Binding	Virus Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Viral Process Protein Ubiquitination Protein Deubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4	Viral Entry Into Host Cell Leukocyte Migration
Pathways		Ub-specific processing proteases Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Cell surface interactions at the vascular wall
Drugs		Dimethyl fumarate Artenimol
Diseases
GWAS		Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Bipolar disorder (body mass index interaction) ( 24322204) Blood pressure (smoking interaction) ( 25189868) Chronic obstructive pulmonary disease ( 30804561 25101718) Diastolic blood pressure ( 27841878) Femoral neck bone mineral density ( 30172743) Height ( 31562340) Lung function (low FEV1 vs high FEV1) ( 26423011) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Monocyte count ( 27863252) Platelet count ( 27863252) Plateletcrit ( 27863252) Red blood cell count ( 29403010) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Severe malaria ( 26416757) Systolic blood pressure ( 27841878) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		49 interacting genes: AK4 AMER1 ATG5 BAD BPTF CAT CCNB1IP1 CDH1 CDK6 CLU CPEB2 CTTN CUL3 EGFR ETF1 FAM117B GLRX5 GYPA HSP90AA1 HSP90AB1 IPO11 IRF1 KLHL3 KPNA6 LSM3 MAD2L1 MAPKBP1 MYO7A NFE2L2 NUDT4 OXR1 PDCD6IP PIDD1 PPP1R13L PRKAG1 PTMA RAF1 RECK RELA SNRPN STK3 STK4 TENT5A TERF1 TRIM15 UBC USP15 WDR83 ZSCAN32	3 interacting genes: CREB3 KEAP1 SGTA
Entrez ID		9817	2993
HPRD ID		12079	07508
Ensembl ID		ENSG00000079999	ENSG00000170180
Uniprot IDs		A0A024R7C0 Q14145	A0A0C4DFT7 A0A2R8Y7F9 E9PD10 P02724 Q14419
PDB IDs		1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B 4XMB 5DAD 5DAF 5F72 5GIT 5NLB 5WFL 5WFV 5WG1 5WHL 5WHO 5WIY 5X54 6FFM 6FMP 6FMQ 6HWS 6ROG	1AFO 1MSR 2KPE 2KPF 5EH4 5EH6
Enriched GO Terms of Interacting Partners?
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