KEAP1 and BPTF

Number of citations of the paper that reports this interaction (PubMedID 15379550)
11

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo, two hybrid)

		KEAP1	BPTF
Description		kelch like ECH associated protein 1	bromodomain PHD finger transcription factor
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Actin Filament Inclusion Body Midbody Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm NURF Complex Extracellular Exosome
	Molecular Function	Protein Binding Transcription Factor Binding Identical Protein Binding Disordered Domain Specific Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Protein Binding DNA-dependent ATPase Activity Transcription Factor Binding Methylated Histone Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Viral Process Protein Ubiquitination Protein Deubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4	Negative Regulation Of Transcription By RNA Polymerase II Embryonic Placenta Development Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Brain Development Endoderm Development Anterior/posterior Pattern Specification Nucleosome Mobilization Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Ub-specific processing proteases Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Dimethyl fumarate Artenimol
Diseases
GWAS		Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Alcohol dependence symptom count ( 27151647) Body mass index ( 28892062) EGFR mutation-positive lung adenocarcinoma ( 27501781) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Hand grip strength ( 29691431) HDL cholesterol ( 30275531) Height ( 31562340) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Lung adenocarcinoma ( 22797724) Lung cancer ( 23143601) Macular thickness ( 30535121) Metabolic syndrome ( 31589552) Neutrophil percentage of granulocytes ( 27863252) Non-small cell lung cancer ( 31326317) Psoriasis ( 25854761) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 30297969)
Interacting Genes		49 interacting genes: AK4 AMER1 ATG5 BAD BPTF CAT CCNB1IP1 CDH1 CDK6 CLU CPEB2 CTTN CUL3 EGFR ETF1 FAM117B GLRX5 GYPA HSP90AA1 HSP90AB1 IPO11 IRF1 KLHL3 KPNA6 LSM3 MAD2L1 MAPKBP1 MYO7A NFE2L2 NUDT4 OXR1 PDCD6IP PIDD1 PPP1R13L PRKAG1 PTMA RAF1 RECK RELA SNRPN STK3 STK4 TENT5A TERF1 TRIM15 UBC USP15 WDR83 ZSCAN32	9 interacting genes: H3-3A H3-4 H4C9 KEAP1 MAZ NFE2L2 SMAD2 SMAD3 SQSTM1
Entrez ID		9817	2186
HPRD ID		12079	03490
Ensembl ID		ENSG00000079999	ENSG00000171634
Uniprot IDs		A0A024R7C0 Q14145	Q12830
PDB IDs		1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B 4XMB 5DAD 5DAF 5F72 5GIT 5NLB 5WFL 5WFV 5WG1 5WHL 5WHO 5WIY 5X54 6FFM 6FMP 6FMQ 6HWS 6ROG	2F6J 2F6N 2FSA 2FUI 2FUU 2RI7 3QZS 3QZT 3QZV 3UV2 5H6Y 6AZE
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?