LSM3 and KLF3

Number of citations of the paper that reports this interaction (PubMedID 30217970)
1

Data Source:
BioGRID (two hybrid)

		LSM3	KLF3
Description		LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated	Kruppel like factor 3
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex	Nuclear Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Binding Protein Binding U6 SnRNA 3'-end Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Cytoplasmic MRNA Processing Body Assembly Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Cellular Response To Peptide
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Chronotype ( 30696823) Height ( 31562340) Offspring birth weight ( 31043758)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Crohn's disease ( 23850713) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Hand grip strength ( 29691431) Helicobacter pylori serologic status ( 23652523) Lymphocyte counts ( 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		40 interacting genes: CCND3 CDKN2D CEP95 CLNS1A CNOT7 DLX4 EEF1A1 EIF4EBP2 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 KEAP1 KLF3 LSM1 LSM10 LSM2 LSM5 LSM6 LSM7 LSM8 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD1 SNRPD3 SNRPE SNRPG TCL1A TFIP11 THOC5 UTP14A WDR77 WDR83 XPC XRN2 YBX1	12 interacting genes: CTBP1 CTBP2 DVL3 EHMT2 FHL3 KDM1A LHX8 LSM3 PIAS1 SUV39H2 TRAF2 UBE2I
Entrez ID		27258	51274
HPRD ID		06283	13920
Ensembl ID		ENSG00000170860	ENSG00000109787
Uniprot IDs		P62310	P57682
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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