GLIS2 and CPSF1

Number of citations of the paper that reports this interaction (PubMedID 17289029)
23

Data Source:
BioGRID (two hybrid)

		GLIS2	CPSF1
Description		GLIS family zinc finger 2	cleavage and polyadenylation specific factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Speck Non-motile Cilium	Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding	Protein Binding Enzyme Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription From RNA Polymerase II Promoter Involved In Kidney Development Cell Differentiation Involved In Kidney Development Positive Regulation Of Protein Localization To Nucleus	MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription MRNA Polyadenylation TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Export From Nucleus MRNA 3'-end Processing Pre-mRNA Cleavage Required For Polyadenylation
Pathways			Transport of Mature mRNA Derived from an Intronless Transcript tRNA processing in the nucleus mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Erectile dysfunction ( 30583798) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 26635082) Prostate-specific antigen levels ( 28139693)	Educational attainment ( 25201988)
Interacting Genes		49 interacting genes: AKT1 ARAF ARNT BCAR1 BECN1 CBLC CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CPSF1 CTNNB1 EPHA2 ERBB2 FGFR4 FZR1 GLIS1 GPSM2 HGF HIF1A LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MDM2 MDM4 MET MYC NF2 NFIC NSD3 PIK3CA RAF1 RASSF1 RBFOX2 SOX3 SPECC1L STK11 TEAD2 TERT TRIM32 U2AF2 WNK1 WT1 XAB2	16 interacting genes: CSTF2T CSTF3 GLIS2 HMOX1 IL7R MCM2 NEDD4 PAPOLA POLR2A PRRC2A REL TAF11 TAF12 TAF13 TAF5 TAF7
Entrez ID		84662	29894
HPRD ID		12256	05823
Ensembl ID		ENSG00000126603	ENSG00000071894
Uniprot IDs		B3KTH4 Q9BZE0	Q10570
PDB IDs			6BLY 6BM0 6DNH 6F9N 6FBS 6FUW 6URG 6URO
Enriched GO Terms of Interacting Partners?
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