GLIS2 and SPECC1L

Number of citations of the paper that reports this interaction (PubMedID 17289029)
23

Data Source:
BioGRID (two hybrid)

		GLIS2	SPECC1L
Description		GLIS family zinc finger 2	sperm antigen with calponin homology and coiled-coil domains 1 like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Speck Non-motile Cilium	Microtubule Organizing Center Spindle Cytosol Gap Junction Actin Cytoskeleton Filamentous Actin
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription From RNA Polymerase II Promoter Involved In Kidney Development Cell Differentiation Involved In Kidney Development Positive Regulation Of Protein Localization To Nucleus	Cell Cycle Cell Adhesion Actin Cytoskeleton Organization Cell Division
Pathways
Drugs
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Erectile dysfunction ( 30583798) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 26635082) Prostate-specific antigen levels ( 28139693)	Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		49 interacting genes: AKT1 ARAF ARNT BCAR1 BECN1 CBLC CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CPSF1 CTNNB1 EPHA2 ERBB2 FGFR4 FZR1 GLIS1 GPSM2 HGF HIF1A LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MDM2 MDM4 MET MYC NF2 NFIC NSD3 PIK3CA RAF1 RASSF1 RBFOX2 SOX3 SPECC1L STK11 TEAD2 TERT TRIM32 U2AF2 WNK1 WT1 XAB2	5 interacting genes: APC ECPAS GLIS2 UBC UBE2I
Entrez ID		84662	23384
HPRD ID		12256	11080
Ensembl ID		ENSG00000126603	ENSG00000100014
Uniprot IDs		B3KTH4 Q9BZE0	B2RMV2 Q69YQ0
PDB IDs
Enriched GO Terms of Interacting Partners?
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