DNMT3A and DNMT3B

Number of citations of the paper that reports this interaction (PubMedID 12145218)
88

Data Source:
HPRD (in vivo, in vitro)

		DNMT3A	DNMT3B
Description		DNA methyltransferase 3 alpha	DNA methyltransferase 3 beta
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Euchromatin XY Body Nucleus Nucleoplasm Nuclear Heterochromatin Cytoplasm Nuclear Matrix	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA Binding Chromatin Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding Transcription Factor Binding DNA-methyltransferase Activity Identical Protein Binding Metal Ion Binding	DNA Binding Chromatin Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Histone Deacetylase Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle DNA Methylation Methylation-dependent Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Spermatogenesis Aging Response To Ionizing Radiation Response To Lead Ion Positive Regulation Of Cell Death Neuron Differentiation Response To Estradiol Response To Vitamin A Response To Cocaine DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Negative Regulation Of Gene Expression, Epigenetic Cellular Response To Amino Acid Stimulus Cellular Response To Ethanol Cellular Response To Hypoxia C-5 Methylation Of Cytosine Hepatocyte Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia DNA Methylation Response To Toxic Substance Response To Ionizing Radiation Positive Regulation Of Gene Expression Response To Activity Response To Caffeine Response To Estradiol Response To Vitamin A Response To Cocaine Positive Regulation Of Neuron Differentiation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Hyperoxia Cellular Response To Dexamethasone Stimulus C-5 Methylation Of Cytosine
Pathways		PRC2 methylates histones and DNA RMTs methylate histone arginines SUMOylation of DNA methylation proteins DNA methylation	PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation
Drugs
Diseases			Other humoral immunodeficiencies, including the following three diseases: Immunodeficiency, centromeric instability, facial anomalies (ICF)-syndrome; kappa light-chain deficiency; Ig heavy chain gene deletions
GWAS		Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 25429064 31562340 18391951) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Macular thickness ( 30535121) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 27863252) Resistant hypertension ( 31545351) Type 1 diabetes ( 21980299) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 28334935) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Nicotine dependence ( 28972577) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Total cholesterol levels ( 30275531)
Interacting Genes		30 interacting genes: CBX1 DDB1 DNMT1 DNMT3B DNMT3L EED EHMT1 EHMT2 EZH2 F8A1 H3C1 H3C6 HDAC1 MYC NRIP1 PIAS1 PIAS2 PRMT5 PTGES3 SETDB1 SP100 SPI1 SUV39H1 TCL1A TERF2IP UBE2I UHRF1 USP7 ZBTB17 ZBTB18	38 interacting genes: BAZ2A CBX1 CBX3 CBX5 CMTM6 CUL4B DDB1 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 H3C1 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS1 ZBTB18
Entrez ID		1788	1789
HPRD ID		04141	04209
Ensembl ID		ENSG00000119772	ENSG00000088305
Uniprot IDs		A0A0C4DG02 F8WE91 Q59HC6 Q9Y6K1	Q9UBC3
PDB IDs		2QRV 3A1A 3A1B 3LLR 3SVM 4QBQ 4QBR 4QBS 4U7P 4U7T 5YX2 6BRR 6F57	3FLG 3QKJ 5CIU 5NR3 5NRR 5NRS 5NRV 5NV0 5NV2 5NV7 5NVO
Enriched GO Terms of Interacting Partners?
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