DNMT3A and EHMT2

  • Number of citations of the paper that reports this interaction (PubMedID 22086334)
  • 40
  • Data Source:
  • BioGRID (enzymatic study)

DNMT3A

EHMT2

Description DNA methyltransferase 3 alpha euchromatic histone lysine methyltransferase 2
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Body mass index ( 26426971)
  • Body mass index (age <50) ( 26426971)
  • Body mass index (age>50) ( 26426971)
  • Body mass index x sex x age interaction (4df test) ( 26426971)
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Crohn's disease ( 28067908 21102463)
  • Heel bone mineral density ( 30598549)
  • Height ( 28552196 25282103 25429064 31562340 18391951)
  • Inflammatory bowel disease ( 28067908)
  • Lymphocyte counts ( 27863252)
  • Lymphocyte percentage of white cells ( 27863252)
  • Macular thickness ( 30535121)
  • Multiple sclerosis ( 31604244)
  • Neutrophil percentage of white cells ( 27863252)
  • Resistant hypertension ( 31545351)
  • Type 1 diabetes ( 21980299)
  • Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
  • Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist circumference adjusted for BMI in active individuals ( 28448500)
  • Waist circumference adjusted for BMI in non-smokers ( 28443625)
  • Waist circumference adjusted for BMI in smokers ( 28443625)
  • Waist circumference adjusted for body mass index ( 25673412 28448500)
  • Anti-thyroid drug induced agranulocytosis ( 27157822)
  • Asthma ( 31619474)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Blood protein levels ( 28240269)
  • Chronic hepatitis B infection ( 25802187 23760081)
  • Chronotype ( 30696823)
  • Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
  • Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
  • Economic and political preferences (environmentalism) ( 22566634)
  • Epstein-Barr virus immune response (EBNA-1) ( 23326239)
  • Idiopathic membranous nephropathy ( 21323541)
  • Inflammatory bowel disease ( 28067908)
  • Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
  • Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
  • Takayasu arteritis ( 25604533)
  • Type 2 diabetes ( 29358691)
  • Ulcerative colitis ( 28067908)
  • Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)
Interacting Genes 30 interacting genes: CBX1 DDB1 DNMT1 DNMT3B DNMT3L EED EHMT1 EHMT2 EZH2 F8A1 H3C1 H3C6 HDAC1 MYC NRIP1 PIAS1 PIAS2 PRMT5 PTGES3 SETDB1 SP100 SPI1 SUV39H1 TCL1A TERF2IP UBE2I UHRF1 USP7 ZBTB17 ZBTB18 48 interacting genes: ABHD17A AURKA CACNA1A CCDC33 CHCHD2 CSNK2A1 CUX1 DNMT3A E4F1 ESR1 FAM161A H1-1 H1-5 H3-3B H3-4 H3C1 H3C14 H3C15 HGS ITGB5 KLF12 KLF3 KLF6 LASP1 LIG1 LIMS1 LMO2 LNX1 MX2 NAA10 NAPRT PLOD3 POR PRRC2B PSMA1 RD3 RELB RERE RPA1 RUVBL2 THAP7 TP53 WIZ XAGE2 ZBTB38 ZNF512B ZNF688 ZNF785
Entrez ID 1788 10919
HPRD ID 04141 06854
Ensembl ID ENSG00000119772 ENSG00000204371
Uniprot IDs A0A0C4DG02 F8WE91 Q59HC6 Q9Y6K1 A0A024RCN9 A2ABF8 B7Z852 Q59FM7 Q96KQ7
PDB IDs 2QRV 3A1A 3A1B 3LLR 3SVM 4QBQ 4QBR 4QBS 4U7P 4U7T 5YX2 6BRR 6F57 2O8J 3DM1 3K5K 3RJW 4NVQ 5JHN 5JIN 5JIY 5JJ0 5T0K 5T0M 5TTF 5TUY 5V9I 5VSC 5VSE 6MM1
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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