DNMT3A and USP7

  • Number of citations of the paper that reports this interaction (PubMedID 21745816)
  • 66

DNMT3A

USP7

Description DNA methyltransferase 3 alpha ubiquitin specific peptidase 7
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Body mass index ( 26426971)
  • Body mass index (age <50) ( 26426971)
  • Body mass index (age>50) ( 26426971)
  • Body mass index x sex x age interaction (4df test) ( 26426971)
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Crohn's disease ( 28067908 21102463)
  • Heel bone mineral density ( 30598549)
  • Height ( 28552196 25282103 25429064 31562340 18391951)
  • Inflammatory bowel disease ( 28067908)
  • Lymphocyte counts ( 27863252)
  • Lymphocyte percentage of white cells ( 27863252)
  • Macular thickness ( 30535121)
  • Multiple sclerosis ( 31604244)
  • Neutrophil percentage of white cells ( 27863252)
  • Resistant hypertension ( 31545351)
  • Type 1 diabetes ( 21980299)
  • Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
  • Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist circumference adjusted for BMI in active individuals ( 28448500)
  • Waist circumference adjusted for BMI in non-smokers ( 28443625)
  • Waist circumference adjusted for BMI in smokers ( 28443625)
  • Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes 30 interacting genes: CBX1 DDB1 DNMT1 DNMT3B DNMT3L EED EHMT1 EHMT2 EZH2 F8A1 H3C1 H3C6 HDAC1 MYC NRIP1 PIAS1 PIAS2 PRMT5 PTGES3 SETDB1 SP100 SPI1 SUV39H1 TCL1A TERF2IP UBE2I UHRF1 USP7 ZBTB17 ZBTB18 99 interacting genes: ABRAXAS2 ACD ANXA1 ARNT2 ATXN1 BCOR BEND5 CBX8 CHEK1 CLSPN CREB3L3 CRY1 CSNK2A1 CTNNB1 DAXX DNAJA3 DNMT3A EWSR1 EZH2 FOXN2 GATA1 H2AC20 H2BU1 HECW1 HERPUD1 HIF1A HTRA2 HUWE1 IFNAR1 KAT5 KDM1A KLHL8 MAGEE1 MAL MARCHF7 MCMBP MDM2 MDM4 MYC MYD88 NECAB2 NOTCH1 OTUD4 PCGF2 PEG3 PEPD PHF8 PHLDB2 PICK1 PLA2G2A PLEKHO1 POLH PPARG PPL PTEN RAD18 RADIL RARA RB1 RBCK1 RELA RFFL RNF168 RNF220 SCML2 SIRT7 SMAD3 SNCA SUMO2 SYVN1 TANK TBCB TFIP11 TMPO TP53 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO UBA52 UBC UBE2D3 UBE2E1 UBE2S USP21 USP28 WWP2 XPC ZMYND8 ZNF423
Entrez ID 1788 7874
HPRD ID 04141 03950
Ensembl ID ENSG00000119772 ENSG00000187555
Uniprot IDs A0A0C4DG02 F8WE91 Q59HC6 Q9Y6K1 B7Z855 B7ZAX6 Q6U8A4 Q93009
PDB IDs 2QRV 3A1A 3A1B 3LLR 3SVM 4QBQ 4QBR 4QBS 4U7P 4U7T 5YX2 6BRR 6F57 1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ 4KG9 4M5W 4M5X 4PYZ 4WPH 4WPI 4YOC 4YSI 4Z96 4Z97 5C56 5C6D 5FWI 5GG4 5J7T 5JTJ 5JTV 5KYB 5KYC 5KYD 5KYE 5KYF 5N9R 5N9T 5NGE 5NGF 5UQV 5UQX 5VS6 5VSB 5VSK 5WHC 6F5H
Enriched GO Terms of Interacting Partners?
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