DNMT3A and ZBTB17

Number of citations of the paper that reports this interaction (PubMedID 15616584)
122

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		DNMT3A	ZBTB17
Description		DNA methyltransferase 3 alpha	zinc finger and BTB domain containing 17
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Euchromatin XY Body Nucleus Nucleoplasm Nuclear Heterochromatin Cytoplasm Nuclear Matrix	Nucleoplasm Protein-containing Complex Protein-DNA Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA Binding Chromatin Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding Transcription Factor Binding DNA-methyltransferase Activity Identical Protein Binding Metal Ion Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Core Promoter Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle DNA Methylation Methylation-dependent Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Spermatogenesis Aging Response To Ionizing Radiation Response To Lead Ion Positive Regulation Of Cell Death Neuron Differentiation Response To Estradiol Response To Vitamin A Response To Cocaine DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Negative Regulation Of Gene Expression, Epigenetic Cellular Response To Amino Acid Stimulus Cellular Response To Ethanol Cellular Response To Hypoxia C-5 Methylation Of Cytosine Hepatocyte Apoptotic Process	Gastrulation With Mouth Forming Second Ectoderm Development Negative Regulation Of Cell Proliferation IRE1-mediated Unfolded Protein Response Negative Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Cycle Arrest
Pathways		PRC2 methylates histones and DNA RMTs methylate histone arginines SUMOylation of DNA methylation proteins DNA methylation	XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 25429064 31562340 18391951) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Macular thickness ( 30535121) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 27863252) Resistant hypertension ( 31545351) Type 1 diabetes ( 21980299) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Erectile dysfunction ( 30583798) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Idiopathic dilated cardiomyopathy ( 21459883)
Interacting Genes		30 interacting genes: CBX1 DDB1 DNMT1 DNMT3B DNMT3L EED EHMT1 EHMT2 EZH2 F8A1 H3C1 H3C6 HDAC1 MYC NRIP1 PIAS1 PIAS2 PRMT5 PTGES3 SETDB1 SP100 SPI1 SUV39H1 TCL1A TERF2IP UBE2I UHRF1 USP7 ZBTB17 ZBTB18	24 interacting genes: BCL6 CDKN2B CREBBP DIS3 DNMT3A E2F6 EP300 ESR1 ESR2 GTF2I HCFC1 HK2 HK3 HSPB1 IRF8 ITGB5 MAX MSX2 MYC MYCN PGR TMPRSS11A TOPBP1 ZBTB7C
Entrez ID		1788	7709
HPRD ID		04141	04968
Ensembl ID		ENSG00000119772	ENSG00000116809
Uniprot IDs		A0A0C4DG02 F8WE91 Q59HC6 Q9Y6K1	Q13105 Q53EM1
PDB IDs		2QRV 3A1A 3A1B 3LLR 3SVM 4QBQ 4QBR 4QBS 4U7P 4U7T 5YX2 6BRR 6F57	2LVR 2LVT 2LVU 2M0D 2M0E 2M0F 2N25 2N26 2Q81 3M52 4U2M 4U2N 5ION
Enriched GO Terms of Interacting Partners?
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