COMP and OTX1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		COMP	OTX1
Description		cartilage oligomeric matrix protein	orthodenticle homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Protein-containing Complex Collagen-containing Extracellular Matrix Extracellular Exosome	Nuclear Chromatin
	Molecular Function	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Heparin Binding BMP Binding Proteoglycan Binding Heparan Sulfate Proteoglycan Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Skeletal System Development Chondrocyte Development Growth Plate Cartilage Development Apoptotic Process Response To Unfolded Protein Protein Secretion Animal Organ Morphogenesis Multicellular Organism Aging Animal Organ Senescence Vascular Smooth Muscle Contraction Protein Processing Extracellular Matrix Organization Collagen Fibril Organization Bone Mineralization Regulation Of Bone Mineralization BMP Signaling Pathway Multicellular Organism Growth Chondrocyte Proliferation Tendon Development Negative Regulation Of Apoptotic Process Skin Development Muscle Fiber Development Artery Morphogenesis Musculoskeletal Movement Neuromuscular Process Limb Development Platelet Aggregation Vascular Smooth Muscle Cell Development Negative Regulation Of Hemostasis Positive Regulation Of Chondrocyte Proliferation	Anterior/posterior Pattern Specification Metencephalon Development Midbrain Development Inner Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Diencephalon Morphogenesis
Pathways		Integrin cell surface interactions ECM proteoglycans
Drugs		Calcium
Diseases		Pseudoachondroplasia (PSACH) Multiple epiphyseal dysplasia (MED)
GWAS		Osteoarthritis (with total hip replacement) ( 28319091) Osteoarthritis biomarkers ( 25057126) QT interval ( 29213071)	Neurociticism ( 29500382) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		4 interacting genes: COL2A1 COL9A1 FN1 OTX1	47 interacting genes: ADAMTSL4 CHIC2 CHRD COMP DPY30 FBLN5 GEMIN8P4 GRN KCNK16 KRT81 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-4 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2A LCE2D LCE4A MDFI MGAT5B MTNR1B RBPMS RGS17 RGS20 SMARCC1 SPRY1 SPRY2 TLE4 TNS2 VWC2L
Entrez ID		1311	5013
HPRD ID		02632	08964
Ensembl ID		ENSG00000105664	ENSG00000115507
Uniprot IDs		P49747	P32242
PDB IDs		3FBY
Enriched GO Terms of Interacting Partners?
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