KLHL2 and ACTC1

Number of citations of the paper that reports this interaction (PubMedID 10397770)
27

Data Source:
BioGRID (far western blotting)

		KLHL2	ACTC1
Description		kelch like family member 2	actin alpha cardiac muscle 1
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Lamellipodium Filopodium I Band Actomyosin, Actin Portion Cell Body Extracellular Exosome Blood Microparticle Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	ATP Binding ATPase Activity Myosin Binding
	Biological Process	Protein Ubiquitination Post-translational Protein Modification	Actin Filament Organization Positive Regulation Of Gene Expression Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Striated Muscle Contraction
Drugs
Diseases			Hypertrophic cardiomyopathy (HCM) Atrial septal defect Dilated cardiomyopathy (DCM)
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)	Axial length ( 24144296) Refractive error ( 20835239)
Interacting Genes		15 interacting genes: ACTC1 BCAM CCDC43 CLK2 CUL3 KLHL12 SDCBP TMA16 TNPO2 TXNDC12 UBE2C UBE2D1 WNK1 WNK4 ZNF114	39 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1
Entrez ID		11275	70
HPRD ID		09311	00015
Ensembl ID		ENSG00000109466	ENSG00000159251
Uniprot IDs		B4DFZ5 E9PEX9 O95198	B3KPP5 P68032
PDB IDs		2XN4 4CHB
Enriched GO Terms of Interacting Partners?
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