ACTC1 and SYNE2

Number of citations of the paper that reports this interaction (PubMedID 12118075)
121

Data Source:
HPRD (in vivo)

		ACTC1	SYNE2
Description		actin alpha cardiac muscle 1	spectrin repeat containing nuclear envelope protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Lamellipodium Filopodium I Band Actomyosin, Actin Portion Cell Body Extracellular Exosome Blood Microparticle Glutamatergic Synapse	Cell Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Cytoplasm Mitochondrion Focal Adhesion Integral Component Of Membrane Sarcoplasmic Reticulum Z Disc Lamellipodium Membrane Filopodium Membrane Nuclear Membrane Nuclear Lumen Sarcoplasmic Reticulum Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Intermediate Filament Cytoskeleton Extracellular Exosome
	Molecular Function	ATP Binding ATPase Activity Myosin Binding	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Actin Filament Organization Positive Regulation Of Gene Expression Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration	Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Centrosome Localization Cytoskeletal Anchoring At Nuclear Membrane Regulation Of Cilium Assembly
Pathways		Striated Muscle Contraction	Meiotic synapsis
Drugs
Diseases		Hypertrophic cardiomyopathy (HCM) Atrial septal defect Dilated cardiomyopathy (DCM)	Emery-Dreifuss muscular dystrophy
GWAS		Axial length ( 24144296) Refractive error ( 20835239)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atrial fibrillation ( 28416818 30061737 29892015 22544366) Blond vs. brown/black hair color ( 30531825) Depression ( 29700475) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 30429480) Psoriasis ( 25854761) Pulmonary function decline ( 22424883) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469)
Interacting Genes		39 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1	9 interacting genes: ACTC1 BRAP CALM1 MAPK3 MAPK8IP2 MTNR1B PML SASH1 UBC
Entrez ID		70	23224
HPRD ID		00015	09763
Ensembl ID		ENSG00000159251	ENSG00000054654
Uniprot IDs		B3KPP5 P68032	Q6MZP0 Q8WXH0
PDB IDs			4DXS 4FI9
Enriched GO Terms of Interacting Partners?
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