ACTC1 and PLEC

Number of citations of the paper that reports this interaction (PubMedID 12136158)
0

Data Source:
HPRD (in vivo)

		ACTC1	PLEC
Description		actin alpha cardiac muscle 1	plectin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Lamellipodium Filopodium I Band Actomyosin, Actin Portion Cell Body Extracellular Exosome Blood Microparticle Glutamatergic Synapse	Cytoplasm Cytosol Intermediate Filament Plasma Membrane Brush Border Focal Adhesion Membrane Sarcoplasm Hemidesmosome Sarcolemma Costamere Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	ATP Binding ATPase Activity Myosin Binding	RNA Binding Actin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Muscle Ankyrin Binding Cadherin Binding
	Biological Process	Actin Filament Organization Positive Regulation Of Gene Expression Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration	Hemidesmosome Assembly Wound Healing Intermediate Filament Cytoskeleton Organization
Pathways		Striated Muscle Contraction	Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins Type I hemidesmosome assembly
Drugs
Diseases		Hypertrophic cardiomyopathy (HCM) Atrial septal defect Dilated cardiomyopathy (DCM)	Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Epidermolysis bullosa, hemidesmosomal, including: Epidermolysis bullosa, generalized atrophic benign (GABEB); Epidermolysis bullosa simplex with pyloric atresia (EBS-PA); Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD); Epidermolysis bullosa simplex, Ogna type (EBS-Ogna)
GWAS		Axial length ( 24144296) Refractive error ( 20835239)	Anti-saccade response ( 29064472) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Diastolic blood pressure ( 30224653) Fibrinogen levels ( 28107422 26561523) Height ( 31562340) Knee osteoarthritis ( 28916551) LDL cholesterol ( 30275531) Mean platelet volume ( 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosquito bite size ( 28199695) Platelet count ( 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Post bronchodilator FEV1 ( 26634245) Resting heart rate ( 27798624) Total cholesterol levels ( 30275531)
Interacting Genes		39 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1	22 interacting genes: ACTC1 ACTG1 ANK3 BRCA2 CASP8 CDK1 COL17A1 EGFR ITGA6 ITGB4 LMNB1 MAP2 MSN MTDH PLEKHA5 PTEN RACK1 SMAD9 SPTA1 SPTAN1 UBC VIM
Entrez ID		70	5339
HPRD ID		00015	03180
Ensembl ID		ENSG00000159251	ENSG00000178209
Uniprot IDs		B3KPP5 P68032	Q15149
PDB IDs			1MB8 2N03 2ODU 2ODV 3F7P 3PDY 3PE0 4GDO 4Q58 4Q59 5J1F 5J1G 5J1H 5J1I
Enriched GO Terms of Interacting Partners?
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