KLHL2 and TXNDC12

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

		KLHL2	TXNDC12
Description		kelch like family member 2	thioredoxin domain containing 12
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex	Cell Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	Protein Binding Peptide Disulfide Oxidoreductase Activity Protein-disulfide Reductase (glutathione) Activity
	Biological Process	Protein Ubiquitination Post-translational Protein Modification	Cell Redox Homeostasis Oxidation-reduction Process Negative Regulation Of Cell Death Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Glutathione
Diseases
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)
Interacting Genes		15 interacting genes: ACTC1 BCAM CCDC43 CLK2 CUL3 KLHL12 SDCBP TMA16 TNPO2 TXNDC12 UBE2C UBE2D1 WNK1 WNK4 ZNF114	5 interacting genes: KLHL2 SGTA SGTB UBQLN1 ZDHHC17
Entrez ID		11275	51060
HPRD ID		09311	11633
Ensembl ID		ENSG00000109466	ENSG00000117862
Uniprot IDs		B4DFZ5 E9PEX9 O95198	O95881
PDB IDs		2XN4 4CHB	1SEN 2K8V
Enriched GO Terms of Interacting Partners?
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