MAP3K2 and SH2D2A

Number of citations of the paper that reports this interaction (PubMedID 12640115)
32

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		MAP3K2	SH2D2A
Description		mitogen-activated protein kinase kinase kinase 2	SH2 domain containing 2A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding	SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Signaling Adaptor Activity
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus	Angiogenesis Signal Transduction Cell Proliferation Positive Regulation Of Signal Transduction Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pathways			VEGFA-VEGFR2 Pathway
Drugs		Bosutinib
Diseases
GWAS		Protein C levels ( 28082259)	Platelet count ( 27863252) SjÃ¶gren's syndrome ( 28076899)
Interacting Genes		25 interacting genes: BIRC2 CTNNB1 IKBKG MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAPK8 NEDD4 NEDD4L NFKBIA NGLY1 PIBF1 PKN2 SH2D2A SMURF1 STAMBP STUB1 USP2 WNK1 XIAP YWHAE YWHAG YWHAZ	29 interacting genes: APPL1 ARID5A CRK DAPK1 EGFR ERBB2 ITK KDR LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1 ZYG11B
Entrez ID		10746	9047
HPRD ID		10068	05152
Ensembl ID		ENSG00000169967	ENSG00000027869
Uniprot IDs		A0A024RAH0 Q9Y2U5	Q5UBZ2 Q5UBZ3 Q9NP31
PDB IDs		2CU1 2NPT 5EX0 5HQ8
Enriched GO Terms of Interacting Partners?
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