MAP3K2 and MAP2K7

Number of citations of the paper that reports this interaction (PubMedID 9372971)
28

Data Source:
HPRD (in vitro, in vivo)

		MAP3K2	MAP2K7
Description		mitogen-activated protein kinase kinase kinase 2	mitogen-activated protein kinase kinase 7
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus	Activation Of MAPK Activity Apoptotic Process Response To Osmotic Stress Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Regulation Of Mitotic Cell Cycle Response To Heat Response To UV Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Telomere Maintenance Via Telomerase Response To Tumor Necrosis Factor Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Stress-activated MAPK Cascade Positive Regulation Of Telomerase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Telomere Capping
Pathways			Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins
Drugs		Bosutinib
Diseases
GWAS		Protein C levels ( 28082259)	Metabolite levels ( 23823483) Type 2 diabetes ( 30297969)
Interacting Genes		25 interacting genes: BIRC2 CTNNB1 IKBKG MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAPK8 NEDD4 NEDD4L NFKBIA NGLY1 PIBF1 PKN2 SH2D2A SMURF1 STAMBP STUB1 USP2 WNK1 XIAP YWHAE YWHAG YWHAZ	32 interacting genes: ARR3 ATF4 CFLAR CNKSR1 DUSP19 DUSP22 GADD45B JUN LPXN LRRK2 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPT RANBP2 RPL30 TRAF6 TRIB1 VRK2
Entrez ID		10746	5609
HPRD ID		10068	04309
Ensembl ID		ENSG00000169967	ENSG00000076984
Uniprot IDs		A0A024RAH0 Q9Y2U5	B4DV95 O14733
PDB IDs		2CU1 2NPT 5EX0 5HQ8	2DYL 3WZU 4UX9 5B2K 5B2L 5B2M 5Y8U 5Y90 5Z1D 5Z1E 6IB0 6IB2 6QFL 6QFR 6QFT 6QG4 6QG7 6QHO 6QHR
Enriched GO Terms of Interacting Partners?
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