SOCS6 and FRS3

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		SOCS6	FRS3
Description		suppressor of cytokine signaling 6	fibroblast growth factor receptor substrate 3
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GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex	Plasma Membrane
	Molecular Function	Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Defense Response JAK-STAT Cascade Negative Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Phosphatidylinositol Phosphorylation Negative Regulation Of T Cell Activation	MAPK Cascade Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway
Pathways		Regulation of KIT signaling Neddylation	FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) Night sleep phenotypes ( 27126917) Systemic lupus erythematosus ( 18204098) Type 2 diabetes ( 29621232)	Menarche (age at onset) ( 25231870)
Interacting Genes		31 interacting genes: ACVR1 APPL1 BMPR1B CLNK CRK DAB1 EFEMP1 EGFR ELOB ELOC FRS3 INSR IRS2 IRS4 KDM1A KIT LNX1 PIK3R1 PIK3R2 PIK3R3 PITRM1 RBCK1 RELA SMURF2 TGFBR1 TUBA1A TUBB4B UBE2D2 UBE2I WDR89 ZMIZ2	28 interacting genes: ADAMTSL4 BMPR2 CBY2 DDX5 FGFR1 GATA1 GRB14 GRB2 KARS1 MAPK1 MATK NOTCH2NLA NTRK1 NTRK2 NUMB PLSCR1 PRKCI PTPN11 RFX6 RND1 SH2B1 SOCS6 SPRY2 TCF4 TLE5 TNS1 TRIP6 VASP
Entrez ID		9306	10817
HPRD ID		05491	06373
Ensembl ID		ENSG00000170677	ENSG00000137218
Uniprot IDs		A0A024R379 O14544	A0A140VJJ7 O43559
PDB IDs		2VIF	2KUP 2KUQ 2YS5 2YT2
Enriched GO Terms of Interacting Partners?
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