TGM2 and HP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TGM2	HP
Gene Name		transglutaminase 2	haptoglobin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Extracellular Vesicular Exosome Endocytic Vesicle Lumen Blood Microparticle
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Metal Ion Binding	Catalytic Activity Protein Binding Antioxidant Activity Hemoglobin Binding
	Biological Process	Blood Vessel Remodeling Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Protein Homooligomerization Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation	Immune System Process Receptor-mediated Endocytosis Defense Response Acute-phase Response Metabolic Process Positive Regulation Of Cell Death Response To Hydrogen Peroxide Defense Response To Bacterium Negative Regulation Of Oxidoreductase Activity Negative Regulation Of Hydrogen Peroxide Catabolic Process
Pathways			Scavenging of heme from plasma
Drugs		Guanosine-5\'-Diphosphate
Diseases
GWAS			Cholesterol, total ( 20686565) Haptoglobin levels ( 22403646) LDL cholesterol ( 20686565) Metabolite levels ( 22916037)
Protein-Protein Interactions		55 interactors: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ATF4 BNIP3 C3 CASP3 COL4A3BP CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 HIST1H2BG HIST2H2BE HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LTBP1 MAP3K12 PAK1 PLCD1 PPHLN1 RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC SUMO1 TAB2 TMEM176A TMSB4X TUBB ZNF512B	20 interactors: ADAMTS4 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL
Entrez ID		7052	3240
HPRD ID		01825	00772
Ensembl ID		ENSG00000198959	ENSG00000257017
Uniprot IDs		B4DIT7 F5H6P0 P21980	P00738 Q6PEJ8
PDB IDs		1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S
Enriched GO Terms of Interacting Partners?		Response To Stress Response To External Stimulus Response To Stimulus Secretion By Cell Establishment Of Localization In Cell Platelet Degranulation Secretion Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Localization Positive Regulation Of Metabolic Process Platelet Activation Regulation Of Cell Proliferation Response To Wounding Regulation Of Signal Transduction Response To Other Organism Positive Regulation Of Cellular Metabolic Process Wound Healing Response To Biotic Stimulus Immune System Process Response To Oxidative Stress Blood Coagulation Response To Organic Substance Hemostasis Regulation Of Cellular Process Regulation Of Signaling Regulation Of Cellular Component Organization Defense Response Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Cellular Response To Stimulus Cell Activation Regulation Of Catalytic Activity Signal Transduction Signaling Exocytosis Regulation Of Body Fluid Levels Positive Regulation Of Protein Metabolic Process Cell Communication Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Metabolic Process Viral Process Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Protein Phosphorylation Response To Abiotic Stimulus	Regulation Of Body Fluid Levels Response To Stress Wound Healing Multicellular Organismal Development Response To Wounding Blood Coagulation Hemostasis Response To Stimulus Tissue Development Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Immune Response Defense Response Developmental Process Positive Regulation Of Cell Death Anatomical Structure Development Homotypic Cell-cell Adhesion Protein Complex Assembly Positive Regulation Of Immune Response System Development Endocytosis Cellular Extravasation Activated T Cell Proliferation Cell Activation Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Reactive Oxygen Species Metabolic Process Cell Adhesion Organ Development Protein Oligomerization Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Immune Response Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Positive Regulation Of Cytoskeleton Organization Gland Development Neutrophil Chemotaxis Positive Regulation Of Immune System Process Morphogenesis Of An Epithelium Neutrophil Migration Leukocyte Migration Single Organismal Cell-cell Adhesion Positive Regulation Of Transforming Growth Factor Beta3 Production Epidermal Cell Division Ectoderm And Mesoderm Interaction Granulocyte Chemotaxis Regulation Of Nitric Oxide Biosynthetic Process
Tagcloud ?		antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately	antibody cd19 cd3 cd4 cd8 controversial dialysis dr hemodialysis hla hs humoral iii miv multivalent parameters percentages phenomenon restore session strikingly subgroups supplementation supplemented uremia vaccinated vaccination zn znso4
Tagcloud (Difference) ?		antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately	antibody cd19 cd3 cd4 cd8 controversial dialysis dr hemodialysis hla hs humoral iii miv multivalent parameters percentages phenomenon restore session strikingly subgroups supplementation supplemented uremia vaccinated vaccination zn znso4
Tagcloud (Intersection) ?