TGM2 and ADAR

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TGM2	ADAR
Gene Name		transglutaminase 2	adenosine deaminase, RNA-specific
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Supraspliceosomal Complex
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Metal Ion Binding	DNA Binding Double-stranded RNA Adenosine Deaminase Activity Protein Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Blood Vessel Remodeling Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Protein Homooligomerization Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation	Osteoblast Differentiation In Utero Embryonic Development Hematopoietic Progenitor Cell Differentiation Somatic Diversification Of Immune Receptors Via Somatic Mutation Adenosine To Inosine Editing MRNA Processing Protein Import Into Nucleus Protein Export From Nucleus Response To Virus Gene Expression Base Conversion Or Substitution Editing MRNA Modification Cytokine-mediated Signaling Pathway Erythrocyte Differentiation Pre-miRNA Processing MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Response To Interferon-alpha Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Definitive Hemopoiesis Type I Interferon Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Hematopoietic Stem Cell Homeostasis Negative Regulation Of RNA Interference
Pathways			Formation of editosomes by ADAR proteins Interferon Signaling Cytokine Signaling in Immune system mRNA Editing: A to I Conversion C6 deamination of adenosine Interferon alpha/beta signaling mRNA Editing
Drugs		Guanosine-5\'-Diphosphate
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		55 interactors: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ATF4 BNIP3 C3 CASP3 COL4A3BP CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 HIST1H2BG HIST2H2BE HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LTBP1 MAP3K12 PAK1 PLCD1 PPHLN1 RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC SUMO1 TAB2 TMEM176A TMSB4X TUBB ZNF512B	5 interactors: ERG HDLBP TGM2 UBE2I XPO1
Entrez ID		7052	103
HPRD ID		01825	07528
Ensembl ID		ENSG00000198959	ENSG00000160710
Uniprot IDs		B4DIT7 F5H6P0 P21980	P55265
PDB IDs		1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S	1QBJ 1QGP 1XMK 2ACJ 2GXB 2L54 3F21 3F22 3F23 3IRQ 3IRR
Enriched GO Terms of Interacting Partners?		Response To Stress Response To External Stimulus Response To Stimulus Secretion By Cell Establishment Of Localization In Cell Platelet Degranulation Secretion Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Localization Positive Regulation Of Metabolic Process Platelet Activation Regulation Of Cell Proliferation Response To Wounding Regulation Of Signal Transduction Response To Other Organism Positive Regulation Of Cellular Metabolic Process Wound Healing Response To Biotic Stimulus Immune System Process Response To Oxidative Stress Blood Coagulation Response To Organic Substance Hemostasis Regulation Of Cellular Process Regulation Of Signaling Regulation Of Cellular Component Organization Defense Response Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Cellular Response To Stimulus Cell Activation Regulation Of Catalytic Activity Signal Transduction Signaling Exocytosis Regulation Of Body Fluid Levels Positive Regulation Of Protein Metabolic Process Cell Communication Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Metabolic Process Viral Process Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Protein Phosphorylation Response To Abiotic Stimulus	Negative Regulation Of Potassium Ion Export Positive Regulation Of SUMO Transferase Activity Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Regulation Of Heart Rate By Hormone Ribosomal Small Subunit Export From Nucleus Peptidyl-amino Acid Modification Peptidyl-lysine Modification Salivary Gland Cavitation Ribosomal Large Subunit Export From Nucleus Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Ribosomal Subunit Export From Nucleus Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Heart Rate By Chemical Signal Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Peptidyl-histidine Phosphorylation Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Negative Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Mitochondrial Calcium Ion Homeostasis Phosphorelay Signal Transduction System Positive Regulation Of Potassium Ion Transmembrane Transport Metal Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter Ventricular Cardiac Muscle Cell Action Potential Response To Drug Regulation Of Membrane Repolarization Negative Regulation Of Potassium Ion Transport Regulation Of Heart Rate By Cardiac Conduction Viral Process Ion Homeostasis Regulation Of Protein Export From Nucleus Protein Sumoylation Intracellular Transport Of Virus Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Branching Involved In Salivary Gland Morphogenesis Apoptotic Cell Clearance Protein Export From Nucleus Endoplasmic Reticulum Calcium Ion Homeostasis Membrane Depolarization During Action Potential Regulation Of Centrosome Duplication Cardiac Muscle Cell Action Potential Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Centrosome Cycle
Tagcloud ?		antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately	adar2 adars adenosines azan azanebularine biophysical deaminase deaminases deaminate deaminated deeper deoxy dsrbd dsrbds duplex edited editing emsa footprinting hadar2 hydrolytically mechanistically misregulation modular nt nucleoside positioning ribonuclease v1
Tagcloud (Difference) ?		antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately	adar2 adars adenosines azan azanebularine biophysical deaminase deaminases deaminate deaminated deeper deoxy dsrbd dsrbds duplex edited editing emsa footprinting hadar2 hydrolytically mechanistically misregulation modular nt nucleoside positioning ribonuclease v1
Tagcloud (Intersection) ?