TGM2 and TAB2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TGM2	TAB2
Gene Name		transglutaminase 2	TGF-beta activated kinase 1/MAP3K7 binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome	Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Metal Ion Binding	Protein Binding Zinc Ion Binding K63-linked Polyubiquitin Binding
	Biological Process	Blood Vessel Remodeling Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Protein Homooligomerization Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Heart Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Pathways			Downstream TCR signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Cytokine Signaling in Immune system Signaling by ERBB4 MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Nuclear signaling by ERBB4 TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs		Guanosine-5\'-Diphosphate
Diseases
GWAS			Breast cancer ( 22383897) Dupuytren's disease ( 21732829)
Protein-Protein Interactions		55 interactors: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ATF4 BNIP3 C3 CASP3 COL4A3BP CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 HIST1H2BG HIST2H2BE HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LTBP1 MAP3K12 PAK1 PLCD1 PPHLN1 RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC SUMO1 TAB2 TMEM176A TMSB4X TUBB ZNF512B	34 interactors: APP CST9L EIF2AK2 ERBB4 ESR1 FN1 FOSL1 GTF2I HDAC1 HDAC3 HDAC5 IKBKB IKBKG IRAK1 MAP3K7 NCOR1 NFKB1 NR2C2 NUMBL PPP2CB SLC19A3 TAB1 TBL1X TGM2 TNFRSF11A TRAF2 TRAF3IP1 TRAF6 UBC UBE2I VIM XIAP YWHAZ ZBTB16
Entrez ID		7052	23118
HPRD ID		01825	05483
Ensembl ID		ENSG00000198959	ENSG00000055208
Uniprot IDs		B4DIT7 F5H6P0 P21980	B4DIR9 Q9NYJ8
PDB IDs		1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S	2DAE 2WWZ 2WX0 2WX1
Enriched GO Terms of Interacting Partners?		Response To Stress Response To External Stimulus Response To Stimulus Secretion By Cell Establishment Of Localization In Cell Platelet Degranulation Secretion Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Localization Positive Regulation Of Metabolic Process Platelet Activation Regulation Of Cell Proliferation Response To Wounding Regulation Of Signal Transduction Response To Other Organism Positive Regulation Of Cellular Metabolic Process Wound Healing Response To Biotic Stimulus Immune System Process Response To Oxidative Stress Blood Coagulation Response To Organic Substance Hemostasis Regulation Of Cellular Process Regulation Of Signaling Regulation Of Cellular Component Organization Defense Response Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Cellular Response To Stimulus Cell Activation Regulation Of Catalytic Activity Signal Transduction Signaling Exocytosis Regulation Of Body Fluid Levels Positive Regulation Of Protein Metabolic Process Cell Communication Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Metabolic Process Viral Process Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Protein Phosphorylation Response To Abiotic Stimulus	Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Cellular Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signaling Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Activation Of Innate Immune Response Cellular Response To Organic Substance Regulation Of Innate Immune Response Cell Communication Positive Regulation Of NIK/NF-kappaB Signaling Signal Transduction Positive Regulation Of Innate Immune Response Regulation Of Gene Expression Defense Response Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of NIK/NF-kappaB Signaling NIK/NF-kappaB Signaling Response To Organic Substance Negative Regulation Of Programmed Cell Death Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Cell Death Regulation Of Transcription, DNA-templated Regulation Of MAPK Cascade
Tagcloud ?		antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately	antioxidative ascertainment cat catalase ceruloplasmin cpl dependence discovered dismutase erythrocytes fig glutathione gpx gsh gssg harmful indirect linear mutual nonenzymatic oxidated peroxidase protected ref relation sod superoxide transferrin trf
Tagcloud (Difference) ?		antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately	antioxidative ascertainment cat catalase ceruloplasmin cpl dependence discovered dismutase erythrocytes fig glutathione gpx gsh gssg harmful indirect linear mutual nonenzymatic oxidated peroxidase protected ref relation sod superoxide transferrin trf
Tagcloud (Intersection) ?