TGM2 and ANKRD28

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TGM2	ANKRD28
Gene Name		transglutaminase 2	ankyrin repeat domain 28
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome	Nucleoplasm
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Metal Ion Binding	Protein Binding
	Biological Process	Blood Vessel Remodeling Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Protein Homooligomerization Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation
Pathways
Drugs		Guanosine-5\'-Diphosphate
Diseases
GWAS
Protein-Protein Interactions		55 interactors: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ATF4 BNIP3 C3 CASP3 COL4A3BP CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 HIST1H2BG HIST2H2BE HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LTBP1 MAP3K12 PAK1 PLCD1 PPHLN1 RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC SUMO1 TAB2 TMEM176A TMSB4X TUBB ZNF512B	4 interactors: AGPAT2 CSNK2B TGM2 ZNF512B
Entrez ID		7052	23243
HPRD ID		01825	10651
Ensembl ID		ENSG00000198959	ENSG00000206560
Uniprot IDs		B4DIT7 F5H6P0 P21980	O15084
PDB IDs		1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S
Enriched GO Terms of Interacting Partners?		Response To Stress Response To External Stimulus Response To Stimulus Secretion By Cell Establishment Of Localization In Cell Platelet Degranulation Secretion Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Localization Positive Regulation Of Metabolic Process Platelet Activation Regulation Of Cell Proliferation Response To Wounding Regulation Of Signal Transduction Response To Other Organism Positive Regulation Of Cellular Metabolic Process Wound Healing Response To Biotic Stimulus Immune System Process Response To Oxidative Stress Blood Coagulation Response To Organic Substance Hemostasis Regulation Of Cellular Process Regulation Of Signaling Regulation Of Cellular Component Organization Defense Response Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Cellular Response To Stimulus Cell Activation Regulation Of Catalytic Activity Signal Transduction Signaling Exocytosis Regulation Of Body Fluid Levels Positive Regulation Of Protein Metabolic Process Cell Communication Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Metabolic Process Viral Process Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Protein Phosphorylation Response To Abiotic Stimulus	Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Epithelium Development Positive Regulation Of Signal Transduction Salivary Gland Cavitation Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Adiponectin-activated Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Tissue Development Endothelial Tube Morphogenesis Tube Morphogenesis CDP-diacylglycerol Biosynthetic Process CDP-diacylglycerol Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Mitochondrial Calcium Ion Homeostasis Morphogenesis Of An Epithelium Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Activin Receptor Signaling Pathway Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Tissue Morphogenesis Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Branching Involved In Salivary Gland Morphogenesis Tube Development Apoptotic Cell Clearance Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Blood Vessel Remodeling Salivary Gland Morphogenesis Triglyceride Biosynthetic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptide Cross-linking Regulation Of Blood Vessel Endothelial Cell Migration Salivary Gland Development Regulation Of Signaling Negative Regulation Of Epithelial Cell Migration Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Smooth Muscle Cell Proliferation Exocrine System Development Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Protein Complex Assembly
Tagcloud ?		antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately	adc aldh1l1 bhlhe40 cggbp1 ctdspl ephb1 fbln2 fgd5 foxp1 gnai2 gorasp1 iqsec1 itga itga9 loc285205 loc285375 lrrc3b lrrn1 mitf nkiras1 noti rbsp3 rpl15 rpl32 thrb ttc21 ube2e2 vhl wnt7a
Tagcloud (Difference) ?		antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately	adc aldh1l1 bhlhe40 cggbp1 ctdspl ephb1 fbln2 fgd5 foxp1 gnai2 gorasp1 iqsec1 itga itga9 loc285205 loc285375 lrrc3b lrrn1 mitf nkiras1 noti rbsp3 rpl15 rpl32 thrb ttc21 ube2e2 vhl wnt7a
Tagcloud (Intersection) ?