HP and CD163

Number of citations of the paper that reports this interaction (PMID 11854028)
26

Data Source:
HPRD (in vivo)

		HP	CD163
Gene Name		haptoglobin	CD163 molecule
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Extracellular Vesicular Exosome Endocytic Vesicle Lumen Blood Microparticle	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Endocytic Vesicle Membrane
	Molecular Function	Catalytic Activity Protein Binding Antioxidant Activity Hemoglobin Binding	Scavenger Receptor Activity Protein Binding
	Biological Process	Immune System Process Receptor-mediated Endocytosis Defense Response Acute-phase Response Metabolic Process Positive Regulation Of Cell Death Response To Hydrogen Peroxide Defense Response To Bacterium Negative Regulation Of Oxidoreductase Activity Negative Regulation Of Hydrogen Peroxide Catabolic Process	Receptor-mediated Endocytosis Acute-phase Response
Pathways		Scavenging of heme from plasma	Scavenging of heme from plasma
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Haptoglobin levels ( 22403646) LDL cholesterol ( 20686565) Metabolite levels ( 22916037)	Hematological and biochemical traits ( 20139978)
Protein-Protein Interactions		20 interactors: ADAMTS4 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL	4 interactors: CSNK2B HP MYH9 PRKCA
Entrez ID		3240	9332
HPRD ID		00772	05708
Ensembl ID		ENSG00000257017	ENSG00000177575
Uniprot IDs		P00738 Q6PEJ8	C9JHR8 Q86VB7
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Body Fluid Levels Response To Stress Wound Healing Multicellular Organismal Development Response To Wounding Blood Coagulation Hemostasis Response To Stimulus Tissue Development Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Immune Response Defense Response Developmental Process Positive Regulation Of Cell Death Anatomical Structure Development Homotypic Cell-cell Adhesion Protein Complex Assembly Positive Regulation Of Immune Response System Development Endocytosis Cellular Extravasation Activated T Cell Proliferation Cell Activation Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Reactive Oxygen Species Metabolic Process Cell Adhesion Organ Development Protein Oligomerization Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Immune Response Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Positive Regulation Of Cytoskeleton Organization Gland Development Neutrophil Chemotaxis Positive Regulation Of Immune System Process Morphogenesis Of An Epithelium Neutrophil Migration Leukocyte Migration Single Organismal Cell-cell Adhesion Positive Regulation Of Transforming Growth Factor Beta3 Production Epidermal Cell Division Ectoderm And Mesoderm Interaction Granulocyte Chemotaxis Regulation Of Nitric Oxide Biosynthetic Process	Regulation Of Blood Vessel Endothelial Cell Migration Response To External Stimulus Chemotaxis Regulation Of Endothelial Cell Migration Negative Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Epithelial Cell Migration Histone H3-T6 Phosphorylation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Platelet Activation Leukocyte Migration Locomotion Negative Regulation Of Hydrogen Peroxide Metabolic Process Cell Cycle Uropod Organization Establishment Of Meiotic Spindle Localization Establishment Of T Cell Polarity Movement Of Cell Or Subcellular Component Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Angiogenesis Positive Regulation Of Activin Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Axon Guidance Regulation Of Hydrogen Peroxide Metabolic Process Endothelial Tube Morphogenesis Negative Regulation Of Glucose Import Blood Coagulation Blood Vessel Morphogenesis Hemostasis Positive Regulation Of Macrophage Differentiation Meiotic Spindle Organization Desmosome Organization Blood Vessel Development Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Immune System Process Axonogenesis Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Vasculature Development Protein Metabolic Process Monocyte Differentiation Membrane Protein Ectodomain Proteolysis Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Axon Development
Tagcloud ?		antibody cd19 cd3 cd4 cd8 controversial dialysis dr hemodialysis hla hs humoral iii miv multivalent parameters percentages phenomenon restore session strikingly subgroups supplementation supplemented uremia vaccinated vaccination zn znso4	27cm3 39cm3 alternatively capacities ccl22 considering correlate cultivation documented emt hazard hcc hepatocellular infiltration injuries invasiveness m2 macrophage macrophages mesenchymal mhcc97l nodules orthotopic proven quantified scavenger snail tumour venous
Tagcloud (Difference) ?		antibody cd19 cd3 cd4 cd8 controversial dialysis dr hemodialysis hla hs humoral iii miv multivalent parameters percentages phenomenon restore session strikingly subgroups supplementation supplemented uremia vaccinated vaccination zn znso4	27cm3 39cm3 alternatively capacities ccl22 considering correlate cultivation documented emt hazard hcc hepatocellular infiltration injuries invasiveness m2 macrophage macrophages mesenchymal mhcc97l nodules orthotopic proven quantified scavenger snail tumour venous
Tagcloud (Intersection) ?