EIF2S1 and CASP6

Number of citations of the paper that reports this interaction (PMID 10734073)
14

Data Source:
HPRD (in vitro)

		EIF2S1	CASP6
Gene Name		eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	caspase 6, apoptosis-related cysteine peptidase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Polysome Eukaryotic Translation Initiation Factor 2 Complex Eukaryotic Translation Initiation Factor 2B Complex Cytoplasmic Stress Granule Membrane Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Translation Initiation Factor Activity Protein Binding Ribosome Binding Poly(A) RNA Binding	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding
	Biological Process	Translation Translational Initiation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Gene Expression Endoplasmic Reticulum Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Cellular Protein Metabolic Process Protein Autophosphorylation	Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Epithelial Cell Differentiation
Pathways		Translation initiation complex formation Recycling of eIF2:GDP Translation L13a-mediated translational silencing of Ceruloplasmin expression Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation PERK regulates gene expression Unfolded Protein Response (UPR)	Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Breakdown of the nuclear lamina Caspase-mediated cleavage of cytoskeletal proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: CASP3 CASP6 CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 MELK P4HB PPP1R15A PRKCD PRKRIR SFN TERT	38 interactors: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 MAPK6 MAPT NEDD4 NUAK1 PCYT1A PIN1 PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 SATB1 SP1 SRF SRP72 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM
Entrez ID		1965	839
HPRD ID		04881	03321
Ensembl ID		ENSG00000134001	ENSG00000138794
Uniprot IDs		P05198 Q53XC0	P55212
PDB IDs		1KL9 1Q8K	1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation In Response To Stress Regulation Of Translation In Response To Stress Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Translational Initiation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Translation In Response To Stress Regulation Of Translation Negative Regulation Of Translation Cellular Response To Stress Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Response To Stress Translation Translational Initiation Oligodendrocyte Development Intrinsic Apoptotic Signaling Pathway Regulation Of Catalytic Activity Apoptotic Process Oligodendrocyte Differentiation Protein Metabolic Process Programmed Cell Death Cellular Response To Stimulus Positive Regulation Of Hydrolase Activity Regulation Of Apoptotic Process Cell Death Death Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Catalytic Activity Regulation Of Cell Death Glial Cell Development Response To Heat Cellular Protein Metabolic Process Response To Glucose Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Negative Regulation Of Cell Death Response To Organic Substance Response To Endoplasmic Reticulum Stress Regulation Of Protein Phosphorylation Response To Stimulus Glial Cell Differentiation Positive Regulation Of Metabolic Process Response To Carbohydrate Gene Expression	Programmed Cell Death Cell Death Death Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Viral Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Tissue Development Response To Stimulus Heart Development Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Cell Communication Regulation Of Protein Kinase Activity Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Neuron Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Signaling Signaling Regulation Of Cell Death Anatomical Structure Morphogenesis Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Neuron Death Skin Development Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Myeloid Cell Differentiation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Organ Development Cell Differentiation Cellular Response To Stimulus Response To Stress Signal Transduction Positive Regulation Of Catalytic Activity Cell Development Positive Regulation Of Proteolysis Immune System Process Regulation Of Phosphorylation Anatomical Structure Development Cellular Response To Organic Substance
Tagcloud ?		atf4 atg7 cerebral contributions counteracted deprivation infarct ischemia ischemic knocking methyladenine mitophagy neuroprotection occluded ogd park2 pba protects releasing rep reperfusion rescue sensor tg thapsigargin tm tmcao transient tunicamycin	5fu aacr abrogating antimetastatic arrests chemoresistance chemoresponse default dissemination disseminative drivers filament hallmark hemidesmosomal itraq junctions phosphorylations phosphorylative prometastatic proteomics reinstate repressing res s25 s38 stathmin stmn1 tethering twin
Tagcloud (Difference) ?		atf4 atg7 cerebral contributions counteracted deprivation infarct ischemia ischemic knocking methyladenine mitophagy neuroprotection occluded ogd park2 pba protects releasing rep reperfusion rescue sensor tg thapsigargin tm tmcao transient tunicamycin	5fu aacr abrogating antimetastatic arrests chemoresistance chemoresponse default dissemination disseminative drivers filament hallmark hemidesmosomal itraq junctions phosphorylations phosphorylative prometastatic proteomics reinstate repressing res s25 s38 stathmin stmn1 tethering twin
Tagcloud (Intersection) ?