EIF2S1 and EIF2AK3

Number of citations of the paper that reports this interaction (PMID 9819435)
156

Data Source:
HPRD (in vitro, in vivo)

		EIF2S1	EIF2AK3
Gene Name		eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	eukaryotic translation initiation factor 2-alpha kinase 3
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Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Polysome Eukaryotic Translation Initiation Factor 2 Complex Eukaryotic Translation Initiation Factor 2B Complex Cytoplasmic Stress Granule Membrane Extracellular Vesicular Exosome	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Translation Initiation Factor Activity Protein Binding Ribosome Binding Poly(A) RNA Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Phosphatase Binding Identical Protein Binding
	Biological Process	Translation Translational Initiation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Gene Expression Endoplasmic Reticulum Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Cellular Protein Metabolic Process Protein Autophosphorylation	Skeletal System Development Ossification Angiogenesis Chondrocyte Development Translation Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process ER Overload Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Organization Lactation Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Translation Peptidyl-serine Phosphorylation Regulation Of Fatty Acid Metabolic Process Calcium-mediated Signaling Insulin Secretion Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Endocrine Pancreas Development Negative Regulation Of Myelination Negative Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Protein Binding SREBP Signaling Pathway Response To Endoplasmic Reticulum Stress Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase I Promoter Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Protein Homooligomerization Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Translation initiation complex formation Recycling of eIF2:GDP Translation L13a-mediated translational silencing of Ceruloplasmin expression Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation PERK regulates gene expression Unfolded Protein Response (UPR)	PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS			Height ( 20881960) Progressive supranuclear palsy ( 21685912)
Protein-Protein Interactions		19 interactors: CASP3 CASP6 CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 MELK P4HB PPP1R15A PRKCD PRKRIR SFN TERT	6 interactors: DNAJC3 EIF2S1 HSP90AA1 HSPA5 IKBKB NFE2L2
Entrez ID		1965	9451
HPRD ID		04881	04942
Ensembl ID		ENSG00000134001	ENSG00000172071
Uniprot IDs		P05198 Q53XC0	B3KY45 Q9NZJ5
PDB IDs		1KL9 1Q8K	4G31 4G34
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation In Response To Stress Regulation Of Translation In Response To Stress Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Translational Initiation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Translation In Response To Stress Regulation Of Translation Negative Regulation Of Translation Cellular Response To Stress Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Response To Stress Translation Translational Initiation Oligodendrocyte Development Intrinsic Apoptotic Signaling Pathway Regulation Of Catalytic Activity Apoptotic Process Oligodendrocyte Differentiation Protein Metabolic Process Programmed Cell Death Cellular Response To Stimulus Positive Regulation Of Hydrolase Activity Regulation Of Apoptotic Process Cell Death Death Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Catalytic Activity Regulation Of Cell Death Glial Cell Development Response To Heat Cellular Protein Metabolic Process Response To Glucose Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Negative Regulation Of Cell Death Response To Organic Substance Response To Endoplasmic Reticulum Stress Regulation Of Protein Phosphorylation Response To Stimulus Glial Cell Differentiation Positive Regulation Of Metabolic Process Response To Carbohydrate Gene Expression	Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Endoplasmic Reticulum Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Response To Stress Cellular Response To Organic Substance Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Protein Metabolic Process Negative Regulation Of Cell Death Regulation Of Nitrogen Compound Metabolic Process Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Protein Metabolic Process Signaling Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Apoptotic Process Cell Communication Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cell Death Positive Regulation Of Transferase Activity Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Protein Catabolic Process Cellular Response To Tumor Necrosis Factor Cellular Response To Cytokine Stimulus Protein Catabolic Process Response To Tumor Necrosis Factor Response To External Stimulus Cellular Response To Stimulus Cerebellum Structural Organization Response To Cytokine Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Biotic Stimulus Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Kinase Activity Cellular Macromolecule Catabolic Process Positive Regulation Of Phosphorylation Protein Import Into Mitochondrial Outer Membrane Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Proteasomal Ubiquitin-independent Protein Catabolic Process
Tagcloud ?		atf4 atg7 cerebral contributions counteracted deprivation infarct ischemia ischemic knocking methyladenine mitophagy neuroprotection occluded ogd park2 pba protects releasing rep reperfusion rescue sensor tg thapsigargin tm tmcao transient tunicamycin	aggregation anilino ans bile bsa chaperone cyclooxygenase dithiothreitol dtt ecor1 hall heat hepatoblastoma hepg2 hydrophobic inactivates marks mount naphthalene perk prevents reduces salt stabilize sulfonate tauroursodeoxycholic tudca unfolded upr
Tagcloud (Difference) ?		atf4 atg7 cerebral contributions counteracted deprivation infarct ischemia ischemic knocking methyladenine mitophagy neuroprotection occluded ogd park2 pba protects releasing rep reperfusion rescue sensor tg thapsigargin tm tmcao transient tunicamycin	aggregation anilino ans bile bsa chaperone cyclooxygenase dithiothreitol dtt ecor1 hall heat hepatoblastoma hepg2 hydrophobic inactivates marks mount naphthalene perk prevents reduces salt stabilize sulfonate tauroursodeoxycholic tudca unfolded upr
Tagcloud (Intersection) ?