EIF2S1 and EIF2B4

Number of citations of the paper that reports this interaction (PMID 8887689)
21

Data Source:
HPRD (in vivo, in vitro)

		EIF2S1	EIF2B4
Gene Name		eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Polysome Eukaryotic Translation Initiation Factor 2 Complex Eukaryotic Translation Initiation Factor 2B Complex Cytoplasmic Stress Granule Membrane Extracellular Vesicular Exosome	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	Translation Initiation Factor Activity Protein Binding Ribosome Binding Poly(A) RNA Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding S-methyl-5-thioribose-1-phosphate Isomerase Activity
	Biological Process	Translation Translational Initiation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Gene Expression Endoplasmic Reticulum Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Cellular Protein Metabolic Process Protein Autophosphorylation	Ovarian Follicle Development Translation Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development L-methionine Biosynthetic Process From Methylthioadenosine Negative Regulation Of Translational Initiation In Response To Stress Myelination Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Negative Regulation Of Translational Initiation Cellular Response To Stimulus
Pathways		Translation initiation complex formation Recycling of eIF2:GDP Translation L13a-mediated translational silencing of Ceruloplasmin expression Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation PERK regulates gene expression Unfolded Protein Response (UPR)	Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: CASP3 CASP6 CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 MELK P4HB PPP1R15A PRKCD PRKRIR SFN TERT	4 interactors: EIF2B2 EIF2B5 EIF2S1 EIF2S2
Entrez ID		1965	8890
HPRD ID		04881	09459
Ensembl ID		ENSG00000134001	ENSG00000115211
Uniprot IDs		P05198 Q53XC0	Q9UI10
PDB IDs		1KL9 1Q8K
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation In Response To Stress Regulation Of Translation In Response To Stress Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Translational Initiation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Translation In Response To Stress Regulation Of Translation Negative Regulation Of Translation Cellular Response To Stress Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Response To Stress Translation Translational Initiation Oligodendrocyte Development Intrinsic Apoptotic Signaling Pathway Regulation Of Catalytic Activity Apoptotic Process Oligodendrocyte Differentiation Protein Metabolic Process Programmed Cell Death Cellular Response To Stimulus Positive Regulation Of Hydrolase Activity Regulation Of Apoptotic Process Cell Death Death Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Catalytic Activity Regulation Of Cell Death Glial Cell Development Response To Heat Cellular Protein Metabolic Process Response To Glucose Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Negative Regulation Of Cell Death Response To Organic Substance Response To Endoplasmic Reticulum Stress Regulation Of Protein Phosphorylation Response To Stimulus Glial Cell Differentiation Positive Regulation Of Metabolic Process Response To Carbohydrate Gene Expression	Translational Initiation Regulation Of Translational Initiation Translation Regulation Of Translational Initiation In Response To Stress Regulation Of Translation In Response To Stress Gonad Development Development Of Primary Sexual Characteristics Regulation Of Translation Sex Differentiation Oligodendrocyte Development Posttranscriptional Regulation Of Gene Expression Reproductive Structure Development Reproductive System Development Ovarian Follicle Development Oligodendrocyte Differentiation Ovulation Cycle Process Developmental Process Involved In Reproduction Glial Cell Development Female Gonad Development Response To Heat Ovulation Cycle Development Of Primary Female Sexual Characteristics Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Response To Glucose Myelination Axon Ensheathment Response To Endoplasmic Reticulum Stress Positive Regulation Of Hydrolase Activity Reproduction Glial Cell Differentiation Response To Carbohydrate Response To Temperature Stimulus Gene Expression Single Organism Reproductive Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Gliogenesis Male Germ Cell Proliferation Reproductive Process Negative Regulation Of Translational Initiation In Response To Stress Rhythmic Process Positive Regulation Of Catalytic Activity Cellular Protein Metabolic Process Negative Regulation Of Translation In Response To Stress Biosynthetic Process Response To Peptide Hormone Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Translational Initiation Response To Peptide
Tagcloud ?		atf4 atg7 cerebral contributions counteracted deprivation infarct ischemia ischemic knocking methyladenine mitophagy neuroprotection occluded ogd park2 pba protects releasing rep reperfusion rescue sensor tg thapsigargin tm tmcao transient tunicamycin	1090c 1980s 314a 318a 877c ataxia atrophy compiled deterioration dystonic genetics hemiparesis hereditary leukoencephalopathy list macrocephaly manifestation matter movements necropsy optic spain spasticity suffered vanishing vwm
Tagcloud (Difference) ?		atf4 atg7 cerebral contributions counteracted deprivation infarct ischemia ischemic knocking methyladenine mitophagy neuroprotection occluded ogd park2 pba protects releasing rep reperfusion rescue sensor tg thapsigargin tm tmcao transient tunicamycin	1090c 1980s 314a 318a 877c ataxia atrophy compiled deterioration dystonic genetics hemiparesis hereditary leukoencephalopathy list macrocephaly manifestation matter movements necropsy optic spain spasticity suffered vanishing vwm
Tagcloud (Intersection) ?