CASP6 and NUAK1

Number of citations of the paper that reports this interaction (PMID 15273717)
11

Data Source:
HPRD (in vitro)

		CASP6	NUAK1
Gene Name		caspase 6, apoptosis-related cysteine peptidase	NUAK family, SNF1-like kinase, 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleolus Cytoplasm Microtubule Cytoskeleton
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding	P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Epithelial Cell Differentiation	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Adhesion Regulation Of Cell Adhesion Regulation Of Myosin-light-chain-phosphatase Activity Regulation Of Cell Proliferation Regulation Of Cellular Senescence
Pathways		Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Breakdown of the nuclear lamina Caspase-mediated cleavage of cytoskeletal proteins
Drugs
Diseases
GWAS			Alzheimer's disease biomarkers ( 23419831)
Protein-Protein Interactions		38 interactors: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 MAPK6 MAPT NEDD4 NUAK1 PCYT1A PIN1 PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 SATB1 SP1 SRF SRP72 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM	6 interactors: APP CASP6 FBXO25 LATS1 PPP1CC UBC
Entrez ID		839	9891
HPRD ID		03321	12171
Ensembl ID		ENSG00000138794	ENSG00000074590
Uniprot IDs		P55212	O60285
PDB IDs		1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA
Enriched GO Terms of Interacting Partners?		Programmed Cell Death Cell Death Death Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Viral Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Tissue Development Response To Stimulus Heart Development Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Cell Communication Regulation Of Protein Kinase Activity Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Neuron Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Signaling Signaling Regulation Of Cell Death Anatomical Structure Morphogenesis Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Neuron Death Skin Development Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Myeloid Cell Differentiation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Organ Development Cell Differentiation Cellular Response To Stimulus Response To Stress Signal Transduction Positive Regulation Of Catalytic Activity Cell Development Positive Regulation Of Proteolysis Immune System Process Regulation Of Phosphorylation Anatomical Structure Development Cellular Response To Organic Substance	Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Glycogen Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Metabolic Process Regulation Of ERBB Signaling Pathway Polysaccharide Metabolic Process Cellular Protein Modification Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus G2/M Transition Of Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Energy Reserve Metabolic Process Notch Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Collateral Sprouting In Absence Of Injury Negative Regulation Of Cellular Protein Metabolic Process Circadian Rhythm Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Protein Metabolic Process Negative Regulation Of Wnt Signaling Pathway Intracellular Receptor Signaling Pathway Cellular Protein Metabolic Process Regulation Of Cell Cycle Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Phase Transition Cellular Carbohydrate Metabolic Process Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Death Death Axon Choice Point Recognition Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition Response To Abiotic Stimulus
Tagcloud ?		5fu aacr abrogating antimetastatic arrests chemoresistance chemoresponse default dissemination disseminative drivers filament hallmark hemidesmosomal itraq junctions phosphorylations phosphorylative prometastatic proteomics reinstate repressing res s25 s38 stathmin stmn1 tethering twin	4e actin actual antilung bp1 chemotaxis contrarily downregulating downregulation excessively hypermethylation invasion invasiveness log luciferase manipulate manipulated matrigel mir mir204 nsclc p70s6k1 polymerisation protein1 rank repress scratch upregulation utr
Tagcloud (Difference) ?		5fu aacr abrogating antimetastatic arrests chemoresistance chemoresponse default dissemination disseminative drivers filament hallmark hemidesmosomal itraq junctions phosphorylations phosphorylative prometastatic proteomics reinstate repressing res s25 s38 stathmin stmn1 tethering twin	4e actin actual antilung bp1 chemotaxis contrarily downregulating downregulation excessively hypermethylation invasion invasiveness log luciferase manipulate manipulated matrigel mir mir204 nsclc p70s6k1 polymerisation protein1 rank repress scratch upregulation utr
Tagcloud (Intersection) ?