CASP6 and SRP72

Number of citations of the paper that reports this interaction (PMID 9857079)
8

Data Source:
HPRD (in vitro)

		CASP6	SRP72
Gene Name		caspase 6, apoptosis-related cysteine peptidase	signal recognition particle 72kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Nucleolus Cytoplasm Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Plasma Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding	Signal Recognition Particle Binding 7S RNA Binding Poly(A) RNA Binding
	Biological Process	Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Epithelial Cell Differentiation	Translation SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Response To Drug Cellular Protein Metabolic Process
Pathways		Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Breakdown of the nuclear lamina Caspase-mediated cleavage of cytoskeletal proteins	Translation SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS			Airflow obstruction ( 22837378)
Protein-Protein Interactions		38 interactors: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 MAPK6 MAPT NEDD4 NUAK1 PCYT1A PIN1 PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 SATB1 SP1 SRF SRP72 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM	5 interactors: CASP3 CASP6 FCHSD2 SKIL SRP68
Entrez ID		839	6731
HPRD ID		03321	03671
Ensembl ID		ENSG00000138794
Uniprot IDs		P55212	O76094
PDB IDs		1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA
Enriched GO Terms of Interacting Partners?		Programmed Cell Death Cell Death Death Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Viral Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Tissue Development Response To Stimulus Heart Development Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Cell Communication Regulation Of Protein Kinase Activity Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Neuron Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Signaling Signaling Regulation Of Cell Death Anatomical Structure Morphogenesis Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Neuron Death Skin Development Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Myeloid Cell Differentiation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Organ Development Cell Differentiation Cellular Response To Stimulus Response To Stress Signal Transduction Positive Regulation Of Catalytic Activity Cell Development Positive Regulation Of Proteolysis Immune System Process Regulation Of Phosphorylation Anatomical Structure Development Cellular Response To Organic Substance	Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Epithelial Cell Differentiation Lymphocyte Homeostasis Execution Phase Of Apoptosis Leukocyte Homeostasis Epithelium Development Homeostasis Of Number Of Cells Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Glial Cell Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Tissue Development Protein Heterotrimerization Negative Regulation Of Activated T Cell Proliferation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Negative Regulation Of Cell Cycle Negative Regulation Of B Cell Proliferation Protein Homotrimerization Apoptotic DNA Fragmentation Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Platelet Formation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Programmed Cell Death Response To Growth Factor Platelet Morphogenesis Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Cell Death Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Hippo Signaling Response To Cytokine Apoptotic Nuclear Changes Release Of Cytochrome C From Mitochondria Lens Fiber Cell Differentiation Protein Trimerization Regulation Of Activated T Cell Proliferation B Cell Homeostasis T Cell Homeostasis Negative Regulation Of B Cell Activation
Tagcloud ?		5fu aacr abrogating antimetastatic arrests chemoresistance chemoresponse default dissemination disseminative drivers filament hallmark hemidesmosomal itraq junctions phosphorylations phosphorylative prometastatic proteomics reinstate repressing res s25 s38 stathmin stmn1 tethering twin	aa alongside aplastic associate autosomal causative coimmunoprecipitation dominant elucidating epitope excreted exome haplotype heterozygous idiopathic incorrectly inheritance inherited localize myelodysplasia nascent particle pathophysiology screen simplex snp tagged telomerase
Tagcloud (Difference) ?		5fu aacr abrogating antimetastatic arrests chemoresistance chemoresponse default dissemination disseminative drivers filament hallmark hemidesmosomal itraq junctions phosphorylations phosphorylative prometastatic proteomics reinstate repressing res s25 s38 stathmin stmn1 tethering twin	aa alongside aplastic associate autosomal causative coimmunoprecipitation dominant elucidating epitope excreted exome haplotype heterozygous idiopathic incorrectly inheritance inherited localize myelodysplasia nascent particle pathophysiology screen simplex snp tagged telomerase
Tagcloud (Intersection) ?