EIF2S1 and SFN

Number of citations of the paper that reports this interaction (PMID 17361185)
58

Data Source:
HPRD (in vitro)

		EIF2S1	SFN
Gene Name		eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	stratifin
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Polysome Eukaryotic Translation Initiation Factor 2 Complex Eukaryotic Translation Initiation Factor 2B Complex Cytoplasmic Stress Granule Membrane Extracellular Vesicular Exosome	Extracellular Space Nucleus Cytoplasm Cytosol Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Translation Initiation Factor Activity Protein Binding Ribosome Binding Poly(A) RNA Binding	Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Phosphoprotein Binding
	Biological Process	Translation Translational Initiation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Gene Expression Endoplasmic Reticulum Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Cellular Protein Metabolic Process Protein Autophosphorylation	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Release Of Cytochrome C From Mitochondria Keratinocyte Development Negative Regulation Of Protein Kinase Activity Apoptotic Process Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Epidermal Cell Division Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Cell Growth Keratinization Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Protein Export From Nucleus Membrane Organization Establishment Of Skin Barrier Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Translation initiation complex formation Recycling of eIF2:GDP Translation L13a-mediated translational silencing of Ceruloplasmin expression Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation PERK regulates gene expression Unfolded Protein Response (UPR)	Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: CASP3 CASP6 CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 MELK P4HB PPP1R15A PRKCD PRKRIR SFN TERT	49 interactors: ABL1 BAD BAX BCR CCAR1 CCDC102B CCNH CDC25B CDK1 CHST1 EEF1A1 EGFR EIF2S1 EIF4B EXO1 FAM189A2 FAM53C FAM9B FOXO4 GPRIN2 HDAC5 HNRNPD ING1 KCNK15 KCNK3 KCNK9 KIAA0408 LONRF1 MAGEA1 MAP3K5 MARK3 MDM4 MKRN3 MST1R NR3C1 PLEKHF2 PLK4 RAB3IP RFFL RFWD2 SAMSN1 TBL3 TP53 TRIM25 TSC2 WDYHV1 YWHAG ZC2HC1C ZFP36
Entrez ID		1965	2810
HPRD ID		04881	03185
Ensembl ID		ENSG00000134001	ENSG00000175793
Uniprot IDs		P05198 Q53XC0	P31947
PDB IDs		1KL9 1Q8K	1YWT 1YZ5 3IQJ 3IQU 3IQV 3LW1 3MHR 3O8I 3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SPR 3T0L 3T0M 3U9X 3UX0 4DAT 4DAU 4DHM 4DHN 4DHO 4DHP 4DHQ 4DHR 4DHS 4DHT 4DHU 4FR3 4HQW 4HRU 4IEA 4JC3 4JDD
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation In Response To Stress Regulation Of Translation In Response To Stress Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Translational Initiation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Translation In Response To Stress Regulation Of Translation Negative Regulation Of Translation Cellular Response To Stress Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Response To Stress Translation Translational Initiation Oligodendrocyte Development Intrinsic Apoptotic Signaling Pathway Regulation Of Catalytic Activity Apoptotic Process Oligodendrocyte Differentiation Protein Metabolic Process Programmed Cell Death Cellular Response To Stimulus Positive Regulation Of Hydrolase Activity Regulation Of Apoptotic Process Cell Death Death Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Catalytic Activity Regulation Of Cell Death Glial Cell Development Response To Heat Cellular Protein Metabolic Process Response To Glucose Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Negative Regulation Of Cell Death Response To Organic Substance Response To Endoplasmic Reticulum Stress Regulation Of Protein Phosphorylation Response To Stimulus Glial Cell Differentiation Positive Regulation Of Metabolic Process Response To Carbohydrate Gene Expression	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Neuron Death Cell Cycle Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Cellular Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Cellular Response To Organonitrogen Compound Regulation Of Phosphorus Metabolic Process Cell Cycle Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Mitotic Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction ERBB Signaling Pathway Regulation Of Protein Kinase Activity Response To Stress Mitotic Cell Cycle Positive Regulation Of Cell Cycle Response To Organic Substance Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Catalytic Activity Cellular Response To Insulin Stimulus G2/M Transition Of Mitotic Cell Cycle Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Mitochondrion Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Hormone Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Intracellular Signal Transduction Cellular Response To Hormone Stimulus Regulation Of Cell Proliferation B Cell Activation Fc Receptor Signaling Pathway
Tagcloud ?		atf4 atg7 cerebral contributions counteracted deprivation infarct ischemia ischemic knocking methyladenine mitophagy neuroprotection occluded ogd park2 pba protects releasing rep reperfusion rescue sensor tg thapsigargin tm tmcao transient tunicamycin	aging alarm amplitude auditory circuits cortico elderly electrophysiologically employed false finding frontal impairments latency limbic memory n4 p3 perform position potentials prefrontal recency serial sternberg subjects task working young
Tagcloud (Difference) ?		atf4 atg7 cerebral contributions counteracted deprivation infarct ischemia ischemic knocking methyladenine mitophagy neuroprotection occluded ogd park2 pba protects releasing rep reperfusion rescue sensor tg thapsigargin tm tmcao transient tunicamycin	aging alarm amplitude auditory circuits cortico elderly electrophysiologically employed false finding frontal impairments latency limbic memory n4 p3 perform position potentials prefrontal recency serial sternberg subjects task working young
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