ASXL1 and IRAG1

Data Source:
BioGRID (affinity chromatography technology)

		ASXL1	IRAG1
Description		ASXL transcriptional regulator 1	inositol 1,4,5-triphosphate receptor associated 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm PR-DUB Complex	Endoplasmic Reticulum Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding	Protein Binding
	Biological Process	Cell Morphogenesis Heart Morphogenesis Transcription, DNA-templated Animal Organ Morphogenesis Negative Regulation Of Lipid Storage Protein Deubiquitination Hemopoiesis Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Monoubiquitinated Histone H2A Deubiquitination Regulation Of Kidney Size Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Thymus Development Bone Marrow Development Homeostasis Of Number Of Cells Lung Saccule Development Glomerular Visceral Epithelial Cell Development	CGMP-mediated Signaling
Pathways		UCH proteinases	cGMP effects
Drugs
Diseases		C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908) Red cell distribution width ( 32888494)
Interacting Genes		6 interacting genes: APP GOLGA6L9 H1-2 SRPK1 STAT3 UBC	2 interacting genes: ITPR1 PRKG1
Entrez ID		171023	10335
HPRD ID		16516	05242
Ensembl ID		ENSG00000171456	ENSG00000072952
Uniprot IDs		Q498B9 Q8IXJ9	Q9Y6F6
PDB IDs
Enriched GO Terms of Interacting Partners?
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