ASXL1 and ID1

Data Source:
BioGRID (affinity chromatography technology)

		ASXL1	ID1
Description		ASXL transcriptional regulator 1	inhibitor of DNA binding 1, HLH protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm PR-DUB Complex	Nucleus Nucleoplasm Golgi Apparatus Centrosome
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding	Protein Binding Protein C-terminus Binding Transcription Factor Binding Identical Protein Binding Protein Dimerization Activity Protein N-terminus Binding Proteasome Binding Transcription Regulator Activity Transcription Regulator Inhibitor Activity
	Biological Process	Cell Morphogenesis Heart Morphogenesis Transcription, DNA-templated Animal Organ Morphogenesis Negative Regulation Of Lipid Storage Protein Deubiquitination Hemopoiesis Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Monoubiquitinated Histone H2A Deubiquitination Regulation Of Kidney Size Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Thymus Development Bone Marrow Development Homeostasis Of Number Of Cells Lung Saccule Development Glomerular Visceral Epithelial Cell Development	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Brain Development Negative Regulation Of Transcription By Transcription Factor Localization Positive Regulation Of Gene Expression Cell Differentiation Neuron Differentiation Negative Regulation Of Protein Binding Positive Regulation Of Actin Filament Bundle Assembly Circadian Regulation Of Gene Expression Cell-abiotic Substrate Adhesion Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Differentiation Negative Regulation Of Transcription, DNA-templated Blood Vessel Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Dendrite Morphogenesis Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis Regulation Of Vasculature Development Cellular Response To Peptide Cellular Response To Dopamine Cellular Response To Nerve Growth Factor Stimulus
Pathways		UCH proteinases	Oncogene Induced Senescence NGF-stimulated transcription
Drugs
Diseases		C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908) Red cell distribution width ( 32888494)	Diastolic blood pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		6 interacting genes: APP GOLGA6L9 H1-2 SRPK1 STAT3 UBC	24 interacting genes: APPL1 ASCL3 CASK COPB1 DNMT3L ELK1 ELK4 GATA4 HES1 IFI16 IKBKG MSGN1 MYF5 MYF6 MYOD1 MYOG PSMD4 RUNX1T1 SUV39H1 TCF12 TCF3 TCF4 TRIM55 TRIM63
Entrez ID		171023	3397
HPRD ID		16516	08980
Ensembl ID		ENSG00000171456	ENSG00000125968
Uniprot IDs		Q498B9 Q8IXJ9	P41134
PDB IDs
Enriched GO Terms of Interacting Partners?
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