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ASXL1 and POLD1
Data Source:
BioGRID
(affinity chromatography technology)
ASXL1
POLD1
Description
ASXL transcriptional regulator 1
DNA polymerase delta 1, catalytic subunit
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
PR-DUB Complex
Nucleotide-excision Repair Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytosol
Membrane
Aggresome
Delta DNA Polymerase Complex
Molecular Function
DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Protein Binding
Retinoic Acid Receptor Binding
Peroxisome Proliferator Activated Receptor Binding
Metal Ion Binding
Nucleotide Binding
DNA Binding
Chromatin Binding
Damaged DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
3'-5'-exodeoxyribonuclease Activity
Metal Ion Binding
4 Iron, 4 Sulfur Cluster Binding
Biological Process
Cell Morphogenesis
Heart Morphogenesis
Transcription, DNA-templated
Animal Organ Morphogenesis
Negative Regulation Of Lipid Storage
Protein Deubiquitination
Hemopoiesis
Response To Retinoic Acid
Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
Monoubiquitinated Histone H2A Deubiquitination
Regulation Of Kidney Size
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Retinoic Acid Receptor Signaling Pathway
Thymus Development
Bone Marrow Development
Homeostasis Of Number Of Cells
Lung Saccule Development
Glomerular Visceral Epithelial Cell Development
Telomere Maintenance
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA-dependent DNA Replication
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair, Gap-filling
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Response To UV
Translesion Synthesis
Telomere Maintenance Via Semi-conservative Replication
Nucleotide-excision Repair, DNA Incision
Cellular Response To UV
DNA Damage Response, Detection Of DNA Damage
DNA Replication Proofreading
Fatty Acid Homeostasis
Error-free Translesion Synthesis
DNA Biosynthetic Process
Pathways
UCH proteinases
Recognition of DNA damage by PCNA-containing replication complex
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
Cytosolic iron-sulfur cluster assembly
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
Drugs
Diseases
C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
GWAS
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Inflammatory bowel disease (
28067908
)
Red cell distribution width (
32888494
)
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
Obesity-related traits (
23251661
)
Interacting Genes
6 interacting genes:
APP
GOLGA6L9
H1-2
SRPK1
STAT3
UBC
22 interacting genes:
ADAMTSL4
ATR
CCND3
CCNE1
CDK2
CDK4
CEP126
CHGB
GINS4
LASP1
MCPH1
PCNA
POLD2
POLD3
POLD4
SUMO2
TERF2IP
TREX2
TRIM55
WRNIP1
XRCC5
YPEL3
Entrez ID
171023
5424
HPRD ID
16516
08882
Ensembl ID
ENSG00000171456
ENSG00000062822
Uniprot IDs
Q498B9
Q8IXJ9
A0A024R4F4
A0A087WYJ2
M0R2B7
P28340
Q308M6
Q59FA0
PDB IDs
6S1M
6S1N
6S1O
6TNY
6TNZ
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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