CASP8AP2 and CASP10

Data Source:
BioGRID (two hybrid)

		CASP8AP2	CASP10
Description		caspase 8 associated protein 2	caspase 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion PML Body	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Transcription Corepressor Activity Death Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Peptidase Activator Activity Involved In Apoptotic Process SUMO Polymer Binding	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Fas Signaling Pathway Negative Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Signaling Pathway Execution Phase Of Apoptosis
Pathways		SUMOylation of transcription cofactors	TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Drugs
Diseases			Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Asthma ( 31959851) Estimated glomerular filtration rate in non-diabetics ( 31451708) Major depressive disorder ( 29317602)	Basal cell carcinoma ( 25855136) Chronic lymphocytic leukemia ( 28165464 23770605) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		19 interacting genes: CALM1 CASP10 CASP8 CREBBP CREM CTBP2 FADD FAS GLUL MX1 NAA10 NR3C2 PML SP100 SREBF2 TCL1A TRAF2 TRIM21 UBE2I	30 interacting genes: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP
Entrez ID		9994	843
HPRD ID		06048	03458
Ensembl ID		ENSG00000118412	ENSG00000003400
Uniprot IDs		Q9UKL3	A0A0S2Z3G5 A0A0S2Z3Z5 Q92851
PDB IDs		2LR8 6ANO 6AOZ 6AP0
Enriched GO Terms of Interacting Partners?
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