CASP8AP2 and MX1

Data Source:
BioGRID (two hybrid)

		CASP8AP2	MX1
Description		caspase 8 associated protein 2	MX dynamin like GTPase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion PML Body	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Axon Cytoplasmic Vesicle Nuclear Membrane Mitochondrial Membrane Dendritic Spine Head Perinuclear Region Of Cytoplasm Presynapse Postsynaptic Endocytic Zone Membrane
	Molecular Function	Transcription Corepressor Activity Death Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Peptidase Activator Activity Involved In Apoptotic Process SUMO Polymer Binding	GTPase Activity Protein Binding GTP Binding Microtubule Binding Identical Protein Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Fas Signaling Pathway Negative Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway	Mitochondrial Fission Dynamin Family Protein Polymerization Involved In Mitochondrial Fission Apoptotic Process Defense Response Signal Transduction Response To Virus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Receptor Internalization Response To Type I Interferon Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of Synapse Structure Or Activity Defense Response To Virus Type I Interferon Signaling Pathway Membrane Fusion Postsynaptic Neurotransmitter Receptor Internalization
Pathways		SUMOylation of transcription cofactors	ISG15 antiviral mechanism Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Asthma ( 31959851) Estimated glomerular filtration rate in non-diabetics ( 31451708) Major depressive disorder ( 29317602)
Interacting Genes		19 interacting genes: CALM1 CASP10 CASP8 CREBBP CREM CTBP2 FADD FAS GLUL MX1 NAA10 NR3C2 PML SP100 SREBF2 TCL1A TRAF2 TRIM21 UBE2I	41 interacting genes: ACTB ADRM1 APP BLM BRD7 C7orf25 CAB39L CASP8AP2 CBX4 CHD3 DAXX EPM2AIP1 FANCA GMEB1 HMGXB4 KIF26B KLHL35 LRRC4B MCCD1 PIAS1 PIAS2 PLRG1 PSD3 RELA SIAH1 SIRPA SLC25A3 SP100 TDG TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TUBA1A TUBB ZBTB16 ZCCHC12 ZNF251 ZNF623
Entrez ID		9994	4599
HPRD ID		06048	00919
Ensembl ID		ENSG00000118412	ENSG00000157601
Uniprot IDs		Q9UKL3	P20591
PDB IDs		2LR8 6ANO 6AOZ 6AP0	3LJB 3SZR 3ZYS 4P4S 4P4T 4P4U 5GTM
Enriched GO Terms of Interacting Partners?
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