CASP10 and CASP14

Data Source:
HPRD (in vivo)

		CASP10	CASP14
Description		caspase 10	caspase 14
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Keratin Filament
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Signaling Pathway Execution Phase Of Apoptosis	Proteolysis Epidermis Development Keratinization Cornification Execution Phase Of Apoptosis
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	Formation of the cornified envelope
Drugs
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Basal cell carcinoma ( 25855136) Chronic lymphocytic leukemia ( 28165464 23770605) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831) Mean corpuscular hemoglobin ( 32888494)	Metabolite levels ( 23823483)
Interacting Genes		30 interacting genes: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP	9 interacting genes: CAPN1 CASP1 CASP10 CASP2 CASP4 CASP8 CDC42 MEOX2 UCHL5
Entrez ID		843	23581
HPRD ID		03458	05788
Ensembl ID		ENSG00000003400	ENSG00000105141
Uniprot IDs		A0A0S2Z3G5 A0A0S2Z3Z5 Q92851	B2CIS9 P31944
PDB IDs
Enriched GO Terms of Interacting Partners?
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