CASP10 and CCAR1

Data Source:
HPRD (in vitro)

		CASP10	CCAR1
Description		caspase 10	cell division cycle and apoptosis regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome	Nucleus Nuclear Envelope Lumen Nucleoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Binding Nuclear Receptor Coactivator Activity
	Biological Process	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Signaling Pathway Execution Phase Of Apoptosis	MRNA Splicing, Via Spliceosome Regulation Of Transcription, DNA-templated Apoptotic Process Cell Cycle Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	mRNA Splicing - Major Pathway
Drugs
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Basal cell carcinoma ( 25855136) Chronic lymphocytic leukemia ( 28165464 23770605) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831) Mean corpuscular hemoglobin ( 32888494)	Cannabis dependence symptom count ( 27028160)
Interacting Genes		30 interacting genes: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP	14 interacting genes: CASP10 CHERP DNAAF6 GOLGA2 HMGB1 HNRNPK MDM2 MIR106B MIRLET7G MTUS2 RBM10 RNF113A SFN U2AF2
Entrez ID		843	55749
HPRD ID		03458	10811
Ensembl ID		ENSG00000003400	ENSG00000060339
Uniprot IDs		A0A0S2Z3G5 A0A0S2Z3Z5 Q92851	Q8IX12
PDB IDs
Enriched GO Terms of Interacting Partners?
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